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박철민
Park, Cheol-Min

박철민

Department of Chemistry(화학과)

  • Synthetic and Medicinal Chemistry Lab.
  • Website
Research Interests
Organic synthesis;medicinal chemistry;Catalysis;유기합성;유기화학;의약화학;촉매
Lab Description
Organic molecules are found as key players in many fields from materials to medicine. Our research focuses on the development of new synthetic methods that facilitate the design and synthesis of bioactive compounds and chemical tools for pharmacological studies.
The access to compounds with unique and diverse structures enables us to explore their potential as novel therapeutic leads, chemical switches and probes. In this regard, organic synthesis forms the foundation of our approach. Heterocyclic compounds represent an important class of compounds that are found in numerous bioactive natural products, drugs, and molecular probes. We have been engaged in the field of heterocycle synthesis by developing new synthetic methods based on metal catalysis. Also, we are actively engaged in developing strategies and methods to generate novel structures and to evaluate their pharmacological intervention including cancer.
Another approach we are undertaking involves rational drug design where the discovery process begins with a hypothesis that the modulation of a target may have therapeutic value. To this end, extensive use of modern discovery tools such as parallel synthesis, computer-aided drug design, x-ray crystallography, and NMR allows us to rapidly identify potential lead compounds and further optimization.
Researcher ID Research Gate ORCiD Scopus Google Scholar
Previous
Synthesis of 2-Quinolones based on Visible Light-Catalyzed Annulation of Diazo compounds File

Bae, Jaehee , Chae, Jiyoung , Park, Cheol-Min

Article Issue Date2024-04 View71
Synthesis of dithioacetals via gold-catalysed hydrothiolation of vinyl sulfides File

Murugesh, Venkatesh , Ryou, Bokyeong , Park, Cheol-Min

Article Issue Date2023-01 View44
Metal- and Oxidant-Free Electrosynthesis of Heterocycles from 1,2-Diarylalkene Derivatives File

Yu, Eunsoo , Kim, Hyungguk , Park, Cheol-Min

Article Issue Date2022-12 View31
Catalyst-free electrosynthesis of benzothiophenes from 2-alkenylaryl disulfides File

Lee, Juyeong , Yu, Eunsoo , Park, Cheol-Min

Article Issue Date2022-09 View29
Electrochemical C(sp(3))-H Functionalization of gamma-Lactams Based on Hydrogen Atom Transfer File

Sim, Jeongwoo , Ryou, Bokyeong , Choi, Minyeong , Lee, Changju , Park, Cheol-Min

Article Issue Date2022-06 View30
A chemical tool for blue light-inducible proximity photo-crosslinking in live cells File

Mishra, Pratyush Kumar , Kang, Myeong-Gyun , Lee, Hakbong , Kim, Seungjoon , Choi, Subin , Sharma, Nirmali , Park, Cheol-Min , Ko, Jaewon , Lee, Changwook , Seo, Jeong Kon , et al

Article Issue Date2022-01 View47
Ortho-selective C-H arylation of phenols with N-carboxyindoles under Bronsted acid- or Cu(i)-catalysis File

Nguyen, Nguyen Hoang , Oh, Soo Min , Park, Cheol-Min , Shin, Seunghoon

Article Issue Date2022-01 View22
Discovery of a dual-action small molecule that improves neuropathological features of Alzheimer's disease mice File File

Park, Min Hee , Park, Kang Ho , Choi, Byung Jo , Han, Wan Hui , Yoon, Hee Ji , Jung, Hye Yoon , Lee, Jihoon , Song, Im-Sook , Lim, Dong Yu , Choi, Min-Koo , et al

Article Issue Date2022-01 View36
Synthesis of Bicyclic N-Heterocycles via Photoredox Cycloaddition of Imino-Alkynes and Imino-Alkenes File

Oh, Hyeonji , Ryou, Bokyeong , Park, Jinhwi , Kim, Minju , Choi, Jun-Ho , Park, Cheol-Min

Article Issue Date2021-11 View31
Programmable site-selective labeling of oligonucleotides based on carbene catalysis File File

Lee, Yang-Ha , Yu, Eunsoo , Park, Cheol-Min

Article Issue Date2021-03 View28
Rational design of metal-ligands for the conversion of CH(4)and CO(2)to acetates: role of acids and Lewis acids File

Bhaskararao, Bangaru , Kim, Dong Yeon , Madridejos, Jenica Marie L. , Park, Cheol-Min , Kim, Kwang S.

Article Issue Date2020-08 View45
Metal-Free Synthesis of Indolopyrans and 2,3-Dihydrofurans Based on Tandem Oxidative Cycloaddition File

Choi, Subin , Oh, Hyeonji , Sim, Jeongwoo , Yu, Eunsoo , Shin, Seunghoon , Park, Cheol-Min

Article Issue Date2020-07 View32
Electrosynthesis of Dihydropyrano[4,3‐b ]indoles Based on a Double Oxidative [3+3] Cycloaddition File

Choi, Subin , Park, Jinhwi , Yu, Eunsoo , Sim, Jeongwoo , Park, Cheol-Min

Article Issue Date2020-07 View32
N-AS-triggered SPMs are direct regulators of microglia in a model of Alzheimer’s disease File File

Lee, Ju Youn , Han, Seung Hoon , Park, Min Hee , Song, Im-Sook , Choi, Min-Koo , Yu, Eunsoo , Park, Cheol-Min , Kim, Hee-Jin , Kim, Seung Hyun , Schuchman, Edward H. , et al

Article Issue Date2020-05 View31
Alkyne-Alkene [2+2] cycloaddition based on visible light photocatalysis File File

Ha, Sujin , Lee, Yeji , Kwak, Yoonna , Mishra, Akash , Yu, Eunsoo , Ryou, Bokyeong , Park, Cheol-Min

Article Issue Date2020-05 View32
Three-Component Synthesis of Quinolines Based on Radical Cascade Visible-Light Photoredox Catalysis File

Cjoi, Jun-Ho , Park, Cheol-Min

Article Issue Date2018-09 View18
Strategic Design of 2,2 '-Bipyridine Derivatives to Modulate Metal Amyloid-beta Aggregation File

Ji, Yonghwan , Lee, Hyuck Jin , Kim, Munjeong , Nam, Geewoo , Lee, Shun Jung C. , Cho. Jaeheung , Park, Cheol-Min , Lim, Mi Hee

Article Issue Date2017-06 View28
alpha-Diazo oxime ethers for N-heterocycle synthesis File

Choi, Subin , Ha, Sujin , Park, Cheol-Min

Article Issue Date2017-06 View34
Synthesis of carbazoles based on gold-copper tandem catalysis File

Choi, Subin , Srinivasulu, Vunnam , Ha, Sujin , Park, Cheol-Min

Article Issue Date2017-03 View13
The synthesis of pyrroles and oxazoles based on gold alpha-imino carbene complexes File

Loy, Nicole S. Y. , Choi, Subin , Kim, Sunggak , Park, Cheol-Min

Article Issue Date2016-06 View30
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