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Park, Cheol-Min
Synthetic & Medicinal Chemistry Lab
Research Interests
  • Organic synthesis, medicinal chemistry, chemical biology

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Alkyne-Alkene [2+2] cycloaddition based on visible light photocatalysis

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Title
Alkyne-Alkene [2+2] cycloaddition based on visible light photocatalysis
Author
Ha, SujinLee, YejiKwak, YoonnaMishra, AkashYu, EunsooRyou, BokyeongPark, Cheol-Min
Issue Date
2020-05
Publisher
NATURE PUBLISHING GROUP
Citation
NATURE COMMUNICATIONS, v.11, no.1, pp.2509
Abstract
UV-activated alkyne-alkene [2+2] cycloaddition has served as an important tool to access cyclobutenes. Although broadly adopted, the limitations with UV light as an energy source prompted us to explore an alternative method. Here we report alkyne-alkene [2+2] cycloaddition based on visible light photocatalysis allowing the synthesis of diverse cyclobutenes and 1,3-dienes via inter- and intramolecular reactions. Extensive mechanistic studies suggest that the localized spin densities at sp(2) carbons of alkenes account for the productive sensitization of alkenes despite their similar triplet levels of alkenes and alkynes. Moreover, the efficient formation of 1,3-dienes via tandem triplet activation of the resulting cyclobutenes is observed when intramolecular enyne cycloaddition is performed, which may serve as a complementary means to the Ru(II)-catalyzed enyne metathesis. In addition, the utility of the [2+2] cycloaddition has been demonstrated by several synthetic transformations including synthesis of various extended pi-systems.
URI
https://scholarworks.unist.ac.kr/handle/201301/32327
URL
https://www.nature.com/articles/s41467-020-16283-9
DOI
10.1038/s41467-020-16283-9
ISSN
2041-1723
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