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- Park, Cheol-Min
- Synthetic and Medicinal Chemistry Lab.
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Electrochemical C(sp(3))-H Functionalization of gamma-Lactams Based on Hydrogen Atom Transfer
- Author(s)
- Sim, Jeongwoo, Ryou, Bokyeong, Choi, Minyeong, Lee, Changju, Park, Cheol-Min
- Issued Date
- 2022-06
- Citation
- ORGANIC LETTERS, v.24, no.23, pp.4264 - 4269
- Abstract
- We describe the electrochemical alpha-amidoalkylation of gamma-lactams based on transition-metal-free cross-coupling via hydrogen atom transfer. The highly selective hydrogen atom transfer process allows for a broad substrate scope including both inter- and intramolecular reactions. Also, the construction of quaternary centers was realized by a double hydrogen atom transfer protocol to afford spirocycles. Detailed mechanistic studies including experimental and computational studies are provided to support the reaction pathway.
- Publisher
- AMER CHEMICAL SOC
- ISSN
- 1523-7060
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