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Cho, Seung Woo (조승우)

Department: Department of Biomedical Engineering(바이오메디컬공학과)

Lab: Genome Engineering Lab. (유전체엔지니어링 연구실)

Research Keywords: Genome engineering, Functional Genomics, Non-coding RNA, ATAC-seq

Research Interests: The human genome contains 3 billion bases. Less than 2 % of the genome codes for protein, and the function of the remaining portion of the genome is not well understood. Recent studies showed the non-coding genome plays critically important roles in gene regulation, but systematic functional studies for non-coding genome are not well established.
The evolution of the development of CRISPR and thigh-throughput technology enables functional studies for non-coding genome. Using those technologies, we aim to identify novel disease-associated aberrations, and provide new strategies for treating incurable diseases based on genome and epigenome editing technologies.

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Issue Date	Title	Author(s)	Type	View	Altmetrics
2023-05	Aptamer Nanoconstructs Crossing Human Blood–Brain Barrier Discovered via Microphysiological System-Based SELEX Technology	Choi, Jeong-Won; Seo, Minwook; Kim, Kyunghwan, et al	ARTICLE	296	Aptamer Nanoconstructs Crossing Human Blood–Brain Barrier Discovered via Microphysiological System-Based SELEX Technology
2023-04	MSH2-MSH3 promotes DNA end resection during HR and blocks TMEJ through interaction with SMARCAD1 and EXO1	Oh, Jung-Min; Kang, Yujin; Park, Jumi, et al	ARTICLE	420
2022-03	Precision targeting tumor cells using cancer-specific InDel mutations with CRISPR-Cas9	Kwon, Taejoon; Ra, Jae Sun; Lee, Soyoung, et al	ARTICLE	743	Precision targeting tumor cells using cancer-specific InDel mutations with CRISPR-Cas9
2021-02	Chromatin accessibility of circulating CD8(+) T cells predicts treatment response to PD-1 blockade in patients with gastric cancer	Shin, Hyun Mu; Kim, Gwanghun; Kim, Sangjib, et al	ARTICLE	523	Chromatin accessibility of circulating CD8(+) T cells predicts treatment response to PD-1 blockade in patients with gastric cancer
2020-12	Cerebellar nuclei evolved by repeatedly duplicating a conserved cell-type set	Kebschull, Justus M.; Richman, Ethan B.; Ringach, Noam, et al	ARTICLE	340	Cerebellar nuclei evolved by repeatedly duplicating a conserved cell-type set
2020-05	Spen links RNA-mediated endogenous retrovirus silencing and X chromosome inactivation	Carter, Ava C.; Xu, Jin; Nakamoto, Meagan Y., et al	ARTICLE	486	Spen links RNA-mediated endogenous retrovirus silencing and X chromosome inactivation
2020-05	Spen links RNA-mediated endogenous retrovirus silencing and X chromosome inactivation	Carter, Ava C.; Xu, Jin; Nakamoto, Meagan Y., et al	ARTICLE	287	Spen links RNA-mediated endogenous retrovirus silencing and X chromosome inactivation
2020-02	CRISPRpic: fast and precise analysis for CRISPR-induced mutations via prefixed index counting	Lee, HoJoon; Chang, Howard Y; Cho, Seung Woo, et al	ARTICLE	521	CRISPRpic: fast and precise analysis for CRISPR-induced mutations via prefixed index counting
2019-01	Coupled Single-Cell CRISPR Screening and Epigenomic Profiling Reveals Causal Gene Regulatory Networks	Rubin, Adam J.; Parker, Kevin R.; Satpathy, Ansuman T., et al	ARTICLE	1108	Coupled Single-Cell CRISPR Screening and Epigenomic Profiling Reveals Causal Gene Regulatory Networks
2018-10	The chromatin accessibility landscape of primary human cancers	Corces, M. Ryan; Granja, Jeffrey M.; Shams, Shadi, et al	ARTICLE	960	The chromatin accessibility landscape of primary human cancers
2018-05	Promoter of lncRNA Gene PVT1 Is a Tumor-Suppressor DNA Boundary Element	Cho, Seung Woo; Xu, Jin; Sun, Ruping, et al	ARTICLE	695	Promoter of lncRNA Gene PVT1 Is a Tumor-Suppressor DNA Boundary Element
2017-11	Enhancer connectome in primary human cells identifies target genes of disease-associated DNA elements	Mumbach, Maxwell R.; Satpathy, Ansuman T.; Boyle, Evan A., et al	ARTICLE	684	Enhancer connectome in primary human cells identifies target genes of disease-associated DNA elements
2017-10	An improved ATAC-seq protocol reduces background and enables interrogation of frozen tissues	Corces, M. Ryan; Trevino, Alexandro E.; Hamilton, Emily G., et al	ARTICLE	777	An improved ATAC-seq protocol reduces background and enables interrogation of frozen tissues
2017-01	CRISPRi-based genome-scale identification of functional long noncoding RNA loci in human cells	Liu, S. John; Horlbeck, Max A.; Cho, Seung Woo, et al	ARTICLE	651	CRISPRi-based genome-scale identification of functional long noncoding RNA loci in human cells
2016-12	ATAC-see reveals the accessible genome by transposase-mediated imaging and sequencing	Chen, Xingqi; Shen, Ying; Draper, Will, et al	ARTICLE	712	ATAC-see reveals the accessible genome by transposase-mediated imaging and sequencing
2015-11	DNA-free genome editing in plants with preassembled CRISPR-Cas9 ribonucleoproteins	Woo, Je Wook; Kim, Jungeun; Il Kwon, Soon, et al	ARTICLE	954	DNA-free genome editing in plants with preassembled CRISPR-Cas9 ribonucleoproteins
2015-01	Site-directed mutagenesis in Arabidopsis thaliana using dividing tissue-targeted RGEN of the CRISPR/Cas system to generate heritable null alleles	Hyun, Youbong; Kim, Jungeun; Cho, Seung Woo, et al	ARTICLE	639	Site-directed mutagenesis in Arabidopsis thaliana using dividing tissue-targeted RGEN of the CRISPR/Cas system to generate heritable null alleles
2015-01	CRISPR engineering turns on genes	Cho, Seung Woo; Chang, Howard Y.	ARTICLE	691	CRISPR engineering turns on genes
2014-06	Highly efficient RNA-guided genome editing in human cells via delivery of purified Cas9 ribonucleoproteins	Kim, Sojung; Kim, Daesik; Cho, Seung Woo, et al	ARTICLE	676	Highly efficient RNA-guided genome editing in human cells via delivery of purified Cas9 ribonucleoproteins
2014-02	Surrogate reporter-based enrichment of cells containing RNA-guided Cas9 nuclease-induced mutations	Ramakrishna, Suresh; Cho, Seung Woo; Kim, Sojung, et al	ARTICLE	669	Surrogate reporter-based enrichment of cells containing RNA-guided Cas9 nuclease-induced mutations

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