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Cho, Seung Woo
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An improved ATAC-seq protocol reduces background and enables interrogation of frozen tissues

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Title
An improved ATAC-seq protocol reduces background and enables interrogation of frozen tissues
Author
Corces, M. RyanTrevino, Alexandro E.Hamilton, Emily G.Greenside, Peyton G.Sinnott-Armstrong, Nicholas A.Vesuna, SamSatpathy, Ansuman T.Rubin, Adam J.Montine, Kathleen S.Wu, BeijingKathiria, ArwaCho, Seung WooMumbach, Maxwell R.Carter, Ava C.Kasowski, MayaOrloff, Lisa A.Risca, Viviana I.Kundaje, AnshulKhavari, Paul A.Montine, Thomas J.Greenleaf, William J.Chang, Howard Y.
Issue Date
2017-10
Publisher
NATURE PUBLISHING GROUP
Citation
NATURE METHODS, v.14, no.10, pp.959
Abstract
We present Omni-ATAC, an improved ATAC-seq protocol for chromatin accessibility profiling that works across multiple applications with substantial improvement of signal-to-background ratio and information content. The Omni-ATAC protocol generates chromatin accessibility profiles from archival frozen tissue samples and 50-mu m sections, revealing the activities of disease-associated DNA elements in distinct human brain structures. The Omni-ATAC protocol enables the interrogation of personal regulomes in tissue context and translational studies.
URI
https://scholarworks.unist.ac.kr/handle/201301/25761
URL
https://www.nature.com/articles/nmeth.4396
DOI
10.1038/NMETH.4396
ISSN
1548-7091
Appears in Collections:
BME_Journal Papers
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