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- Cho, Seung Woo
- Genome Engineering Lab.
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An improved ATAC-seq protocol reduces background and enables interrogation of frozen tissues
- Author(s)
- Corces, M. Ryan, Trevino, Alexandro E., Hamilton, Emily G., Greenside, Peyton G., Sinnott-Armstrong, Nicholas A., Vesuna, Sam, Satpathy, Ansuman T., Rubin, Adam J., Montine, Kathleen S., Wu, Beijing, Kathiria, Arwa, Cho, Seung Woo, Mumbach, Maxwell R., Carter, Ava C., Kasowski, Maya, Orloff, Lisa A., Risca, Viviana I., Kundaje, Anshul, Khavari, Paul A., Montine, Thomas J., Greenleaf, William J., Chang, Howard Y.
- Issued Date
- 2017-10
- Citation
- NATURE METHODS, v.14, no.10, pp.959
- Abstract
- We present Omni-ATAC, an improved ATAC-seq protocol for chromatin accessibility profiling that works across multiple applications with substantial improvement of signal-to-background ratio and information content. The Omni-ATAC protocol generates chromatin accessibility profiles from archival frozen tissue samples and 50-mu m sections, revealing the activities of disease-associated DNA elements in distinct human brain structures. The Omni-ATAC protocol enables the interrogation of personal regulomes in tissue context and translational studies.
- Publisher
- NATURE PUBLISHING GROUP
- ISSN
- 1548-7091
- Keyword
- OPEN CHROMATIN, DNA, LANDSCAPE, GENOME, BRAIN, CELLS, ACCESSIBILITY, DISEASE, INNATE
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