사진

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Park, Cheol-Min (박철민)

Department
화학과
Website
https://sites.google.com/site/cmparklab/home
Lab
Synthetic and Medicinal Chemistry Lab. (유기합성 및 의약화학 연구실)
Research Keywords
유기합성, 유기화학, 의약화학, 촉매, Organic synthesis, medicinal chemistry, Catalysis
Research Interests
Organic molecules are found as key players in many fields from materials to medicine. Our research focuses on the development of new synthetic methods that facilitate the design and synthesis of bioactive compounds and chemical tools for pharmacological studies.
The access to compounds with unique and diverse structures enables us to explore their potential as novel therapeutic leads, chemical switches and probes. In this regard, organic synthesis forms the foundation of our approach. Heterocyclic compounds represent an important class of compounds that are found in numerous bioactive natural products, drugs, and molecular probes. We have been engaged in the field of heterocycle synthesis by developing new synthetic methods based on metal catalysis. Also, we are actively engaged in developing strategies and methods to generate novel structures and to evaluate their pharmacological intervention including cancer.
Another approach we are undertaking involves rational drug design where the discovery process begins with a hypothesis that the modulation of a target may have therapeutic value. To this end, extensive use of modern discovery tools such as parallel synthesis, computer-aided drug design, x-ray crystallography, and NMR allows us to rapidly identify potential lead compounds and further optimization.
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Issue DateTitleAuthor(s)TypeViewAltmetrics
2020-08Rational design of metal-ligands for the conversion of CH(4)and CO(2)to acetates: role of acids and Lewis acidsBhaskararao, Bangaru; Kim, Dong Yeon; Madridejos, Jenica Marie L., et alARTICLE14 Rational design of metal-ligands for the conversion of CH(4)and CO(2)to acetates: role of acids and Lewis acids
2020-07Metal-Free Synthesis of Indolopyrans and 2,3-Dihydrofurans Based on Tandem Oxidative CycloadditionChoi, Subin; Oh, Hyeonji; Sim, Jeongwoo, et alARTICLE14 Metal-Free Synthesis of Indolopyrans and 2,3-Dihydrofurans Based on Tandem Oxidative Cycloaddition
2020-05Electrosynthesis of Dihydropyrano[4,3‐b ]indoles Based on a Double Oxidative [3+3] CycloadditionChoi, Subin; Park, Jinhwi; Yu, Eunsoo, et alARTICLE30 Electrosynthesis of Dihydropyrano[4,3‐b ]indoles Based on a Double Oxidative [3+3] Cycloaddition
2020-05N-AS-triggered SPMs are direct regulators of microglia in a model of Alzheimer’s diseaseLee, Ju Youn; Han, Seung Hoon; Park, Min Hee, et alARTICLE64 N-AS-triggered SPMs are direct regulators of microglia in a model of Alzheimer’s disease
2020-05Alkyne-Alkene [2+2] cycloaddition based on visible light photocatalysisHa, Sujin; Lee, Yeji; Kwak, Yoonna, et alARTICLE52 Alkyne-Alkene [2+2] cycloaddition based on visible light photocatalysis
2018-09Three-Component Synthesis of Quinolines Based on Radical Cascade Visible-Light Photoredox CatalysisCjoi, Jun-Ho; Park, Cheol-MinARTICLE378 Three-Component Synthesis of Quinolines Based on Radical Cascade Visible-Light Photoredox Catalysis
2017-06alpha-Diazo oxime ethers for N-heterocycle synthesisChoi, Subin; Ha, Sujin; Park, Cheol-MinARTICLE567 alpha-Diazo oxime ethers for N-heterocycle synthesis
2017-06Strategic Design of 2,2 '-Bipyridine Derivatives to Modulate Metal Amyloid-beta AggregationJi, Yonghwan; Lee, Hyuck Jin; Kim, Munjeong, et alARTICLE670 Strategic Design of 2,2 '-Bipyridine Derivatives to Modulate Metal Amyloid-beta Aggregation
2017-03Synthesis of carbazoles based on gold-copper tandem catalysisChoi, Subin; Srinivasulu, Vunnam; Ha, Sujin, et alARTICLE509 Synthesis of carbazoles based on gold-copper tandem catalysis
2016-06The synthesis of pyrroles and oxazoles based on gold alpha-imino carbene complexesLoy, Nicole S. Y.; Choi, Subin; Kim, Sunggak, et alARTICLE519 The synthesis of pyrroles and oxazoles based on gold alpha-imino carbene complexes
2016-01Epitaxial Growth of Thin Ferroelectric Polymer Films on Graphene Layer for Fully Transparent and Flexible Nonvolatile MemoryKim, Kang Lib; Lee, Wonho; Hwang, Sun Kak, et alARTICLE977 Epitaxial Growth of Thin Ferroelectric Polymer Films on Graphene Layer for Fully Transparent and Flexible Nonvolatile Memory
2015-02Synthesis of unsymmetrical pyrazines based on α-diazo oxime ethersLoy, Nicole S. Y.; Kim, Sunggak; Park, Cheol-MinARTICLE737 Synthesis of unsymmetrical pyrazines based on α-diazo oxime ethers
2014-07Transition-metal-free synthesis of substituted pyridines via ring expansion of 2-allyl-2H-azirinesJiang, Yaojia; Park, Cheol-Min; Loh, Teck-PengARTICLE688 Transition-metal-free synthesis of substituted pyridines via ring expansion of 2-allyl-2H-azirines
2014-06A catalyst-controlled selective synthesis of pyridines and pyrrolesJiang, Yaojia; Park, Cheol-MinARTICLE627 A catalyst-controlled selective synthesis of pyridines and pyrroles
2013-02ABT-199, a potent and selective BCL-2 inhibitor, achieves antitumor activity while sparing plateletsSouers, Andrew J.; Leverson, Joel D.; Boghaert, Erwin R., et alARTICLE688 ABT-199, a potent and selective BCL-2 inhibitor, achieves antitumor activity while sparing platelets
2013-02Synthesis of Pyridines by Carbenoid-Mediated Ring Opening of 2H-AzirinesLoy, Nicole S. Y.; Singh, Alok; Xu, Xianxiu, et alARTICLE679 Synthesis of Pyridines by Carbenoid-Mediated Ring Opening of 2H-Azirines
2012-10Carbenoid-mediated N-O bond insertion and its application in the synthesis of pyridinesQi, Xinxin; Dai, Lu; Park, Cheol-MinARTICLE627 Carbenoid-mediated N-O bond insertion and its application in the synthesis of pyridines
2012-04Facile synthesis of 2-alkyl/aryloxy-2H-azirines and their application in the synthesis of pyrrolesQi, Xinxin; Xu, Xianxiu; Park, Cheol-MinARTICLE538 Facile synthesis of 2-alkyl/aryloxy-2H-azirines and their application in the synthesis of pyrroles
2012-03Synthesis of 2-aminofurans and 2-unsubstituted furans via carbenoid-mediated [3+2] cycloadditionJiang, Yaojia; Khong, Vanessa Zhong Yue; Lourdusamy, Emmanuvel, et alARTICLE500 Synthesis of 2-aminofurans and 2-unsubstituted furans via carbenoid-mediated [3+2] cycloaddition
2012-03Expedient Synthesis of Highly Substituted Pyrroles via Tandem Rearrangement of alpha-Diazo Oxime EthersJiang, Yaojia; Chan, Wei Chuen; Park, Cheol-MinARTICLE520 Expedient Synthesis of Highly Substituted Pyrroles via Tandem Rearrangement of alpha-Diazo Oxime Ethers

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