Scholarworks@UNIST: Browsing Repository

A novel TRAP1 inhibitor, containing flexible triphenylphosphonium, interacted with an allosteric site involving E403 residue and triggered protein conformational changes

Yoon, Nam Gu , Kang, Byoung Heon

Conference Paper Issue Date2018-10-20 View9

A novel TRAP1 inhibitor, UB-010 potently inactivates the mitochondrial chaperoneby interacting with the client binding site.

Yoon, Nam Gu , Hu, Sung , Kim. So-Yeon , Lee, Changwook , Kang, Byoung Heon

Conference Paper Issue Date2020-10-08 View8

Anticancer strategy targeting mitochondrial Hsp90 in breast tumor envionment

Yoon, Nam Gu , Kang, Byoung Heon

Conference Paper Issue Date2023-09-15 View5

Caspase-3 has enhanced proteolytic properties at acidic pH

Kang, Byoung Heon

Conference Paper Issue Date2002 View6

Characterization of active-site residues of the NIa protease from tobacco vein mottling virus File

Hwang, DC , Kim, DH , Lee, JS , Kang, Byoung Heon , Han, J , Kim, W , Song, BD , Choi, KY

Article Issue Date2000-10 View9

Characterization of Nla protease from turnip mosaic potyvirus exhibiting a low-temperature optimum catalytic activity File

Kim, DH , Hwang, D , Kang, Byoung Heon , Lew, J , Choi, KY

Article Issue Date1996-07 View8

Chemical approaches to development of mitochondrial-targeted Hsp90 inhibitor as anti-cancer drug: Mechanism and conformational change of mitochondrial Hsp90

Hu, Sung , Yoon, Nam gu , Jung, Hyun suck , Han, In cheol , Kang, Byoung Heon

Conference Paper Issue Date2017-05-18 View7

Chemical approaches to development of mitochondrial-targeted Hsp90 inhibitor as anti-cancer therapeutics: Mechanism and conformational change of mitochondrial Hsp90

Hu, Sung , Yoon, Nam Gu , Kang, Byoung Heon

Conference Paper Issue Date2017-04-03 View5

Combination effect on Gamitrinib-TPP on tamoxifen-resistant breast cancer cell line

Kang, Byoung Heon , None

Conference Paper Issue Date2013 View6

Combination treatment with doxorubicin and gamitrinib synergistically augments anticancer activity through enhanced activation of Bim File File

Park, Hye-Kyung , Lee, Ji-Eun , Lim, Jaehwa , Jo, Da-Eun , Park, Soo-Ah , Suh, Pann-Ghill , Kang, Byoung Heon

Article Issue Date2014-06 View14

Combinatorial drug design targeting multiple cancer signaling networks controlled by mitochondrial Hsp90 File

Kang, Byoung Heon , Plescia, Janet , Song, Ho Young , Meli, Massimiliano , Colombo, Giorgio , Beebe, Kristin , Scroggins, Bradley , Neckers, Len , Altieri, Dario C.

Article Issue Date2009-03 View8

Compartmentalized cancer drug discovery targeting mitochondrial Hsp90 chaperones File

Kang, Byoung Heon , Altieri, D. C.

Article Issue Date2009-10 View4

Crystallization and preliminary X-ray diffraction analysis of Trap1 complexed with Hsp90 inhibitors File

Kang, Byoung Heon , Jeong, Hanbin , Lee, Changwook

Article Issue Date2014-12 View9

Cyclophilin D defect impairs ROS regulation and increases invasion of cancer cells

Park,Hye-Kyung , Kang, Byoung Heon

Conference Paper Issue Date2017-05-31 View4

Cytotoxic effects of Tenebrio molitor larval extracts against hepatocellular carcinoma File

Lee, ji-Eun , Lee, An-Jung , Jo, Da-Eun , Cho, Ju Hyeong , Youn, Kumju , Yun, Eun-Young , Hwang, Jae-Sam , Jun, Mira , Kang, Byoung Heon

Article Issue Date2015-02 View13

Design and Synthesis of TRAP1 Selective Inhibitors: H-Bonding with Asn171 Residue in TRAP1 Increases Paralog Selectivity File

Yang, Sujae , Yoon, Nam Gu , Kim, Dongyoung , Park, Eunsun , Kim, So-Yeon , Lee, Ji Hoon , Lee, Changwook , Kang, Byoung Heon , Kang, Soosung

Article Issue Date2021-07 View22

Development of a Mitochondria-Targeted Hsp90 Inhibitor Based on the Crystal Structures of Human TRAP1 File

Lee, Changwook , Park, Hye-Kyung , Jeong, Hanbin , Lim, Jaehwa , Lee, An-Jung , Cheon, Keun Young , Kim, Chul-Su , Thomas, Ajesh P. , Bae, Boram , Kim, Nam Doo , et al

Article Issue Date2015-04 View18

Development of Hsp90 family protein inhibitors

Park, Hye-Kyung , Ko, Eunhwa , Lee, Geumwoo , Lee, Ji-Eun , Lee, Sang Kwang , Jeong, Hanbin , Lee, An-Jung , Im, Jin Young , Kim, Seong Heon , Lee, Changwook , et al

Conference Paper Issue Date2016-12-09 View6

Development of Hsp90 paralog specific inhibitors with mitochondrial drug delivery system

Kang, Byoung Heon

Conference Paper Issue Date2015-11-12 View3

Development of Hsp90 paralog specific inhibitors with mitochondrial drug delivery system File

Kang, Byoung Heon

Conference Paper Issue Date2015-04-18 View3

Development of Hsp90 paralog specific inhibitors with mitochondrial drug delivery system

Kang, Byoung Heon

Conference Paper Issue Date2015-04-20 View4

Development of in vivo pan-Hsp90 inhibitors as cancer therapeutics

Kang, Byoung Heon

Conference Paper Issue Date2016-06-23 View4

Development of mitochondria-targeted Hsp90 inhibitor as a anti-cancer drug

Park, Hye-Jyung , Ko, Eunhwa , Lee, Gemwoo , Lee, Ji-Eun , Lee, Sang Kwang , Jeong, Hanbin , Lee, An-Jung , Im, Jing Young , Hu, Sung , Kim, Seong Heon , et al

Conference Paper Issue Date2016-11-25 View3

Development of mitochondria-targeted Hsp90 inhibitors as effective cancer therapeutics

Kang, Byoung Heon

Conference Paper Issue Date2011 View4

Development of mitochondria-targeted inhibitor SMTIN-P01 and in vivo pan-Hsp90 inhibitors as cancer therapeutics

Kang, Byoung Heon

Conference Paper Issue Date2015-10-15 View4

Development of mitochondria-targeted TRAP1 inhibitors and in vivo pan-Hsp90 inhibitors as cancer therapeutics

Kang, Byoung Heon

Conference Paper Issue Date2015-11-20 View2

Development of pyrazolo[3,4-d]pyrimidine-6-amine-based TRAP1 inhibitors that demonstrate in vivo anticancer activity in mouse xenograft models File

Kim, Darong , Kim, So-Yeon , Kim, Dongyoung , Yoon, Nam Gu , Yun, Jisu , Hong, Ki Bum , Lee, Changwook , Lee, Ji Hoon , Kang, Byoung Heon , Kang, Soosung

Article Issue Date2020-08 View25

Development of small molecule inhibitors targeting the mitochondrial chaperone TRAP1 as a cancer therapeutics

Kang, Byoung Heon

Conference Paper Issue Date2023-11-30 View10

Development of TRAP1 inhibitors as cancer therapeutics

Kang, Byoung Heon

Conference Paper Issue Date2018-10-20 View7

Development of TRAP1 inhibitors to treat cancers and other human diseases

Kang, Byoung Heon

Conference Paper Issue Date2022-10-21 View5

Developmental Control of Apoptosis by the Immunophilin Aryl Hydrocarbon Receptor-interacting Protein (AIP) Involves Mitochondrial Import of the Survivin Protein File

Kang, Byoung Heon , Xia, Fang , Pop, Ramona , Dohi, Takehiko , Socolovsky, Merav , Altieri, Dario C.

Article Issue Date2011-05 View6

Discovery of 2-((4-resorcinolyl)-5-aryl-1,2,3-triazol-1-yl)acetates as potent Hsp90 inhibitors with selectivity over TRAP1 File

Jung, Sejin , Yoon, Nam Gu , Yang, Sujae , Kim, Darong , Lee, Won Seok , Hong, Ki Bum , Lee, Changwook , Kang, Byoung Heon , Lee, Ji Hoon , Kang, Soosung

Article Issue Date2020-01 View13

Dual Binding to Orthosteric and Allosteric Sites Enhances the Anticancer Activity of a TRAP1-Targeting Drug File

Hu, Sung , Ferraro, Mariarosaria , Thomas, Ajesh P. , Chung, Jeong Min , Yoon, Nam Gu , Seol, Ji-Hoon , Kim, Sangpil , Kim, Han-Ul , An, Mi Young , Ok, Haewon , et al

Article Issue Date2020-03 View9

Effects of internal cleavages and mutations in the C-terminal region of NIa protease of turnip mosaic potyvirus on the catalytic activity File

Kim, DH , Hwang, DC , Kang, Byoung Heon , Lew, J , Han, JS , Song, BOD , Choi, KY

Article Issue Date1996-12 View13

Effects of mutations in the C-terminal region of NIa protease on cis-cleavage between NIa and NIb File

Kim, DH , Han, JS , Lew, JS , Kim, SS , Kang, Byoung Heon , Hwang, DC , Jang, DS , Kim, W , Song, BD , Choi, KY

Article Issue Date1998-02 View4

Expression, Purification and Characterization of the Precursor and Mature Forms of Caspase-6

Kang, Byoung Heon

Conference Paper Issue Date2000-01-01 View5

Flightless-1 inhibits ER stress-induced apoptosis in colorectal cancer cells by regulating Ca2+ homeostasis File File

Choi, Sun Sil , Lee, Sang Kwon , Kim, Joong Kwan , Park, Hye-Kyung , Lee, Eujin , Jang, Jinho , Lee, Yo Han , Khim, Keon Woo , Hyun, Ji-Min , Eom, Hye-jin , et al

Article Issue Date2020-06 View25

Function of mitochondrial chaperone TRAP1 during progression of metabolic diseases

Kang, Byoung Heon

Conference Paper Issue Date2019-11-02 View7

Function of mitochondrial HSP90 in tumor angiogenesis

Kim, So Yeon , Yoon, Nam Gu , Kim, Eun Hye , Kang, Byoung Heon

Conference Paper Issue Date2020-10-08 View7

Function of mitochondrial HSP90 in tumor microenvironment

Kim, So Yeon , Yoon, Nam Gu , Kang, Byoung Heon

Conference Paper Issue Date2021-12-10 View7

Function of mitochondrial HSP90 in tumor micronenvironment

Kim, So Yeon , Yoon, Nam Gu , Kang, Byoung Heon

Conference Paper Issue Date2021-08-25 View6

Function of the mitochondrial chaperone in ischemic retinopathy.

Kim, So-Yeon , Yoon, Nam Gu , Kang, Byoung Heon , Park, Dong Ho

Conference Paper Issue Date2023-09-15 View6

Function of the mitochondrial chaperone TRAP1 in ischemic retinopathy

Kim, So Yeon , Yoon, Nam Gu , Im, Jin Young , Kim, Juhee , Jeon, Yu Jin , Choi, Young Jae , Lee, Jong-Hwa , Uemura, Akiyoshi , Kang, Byoung Heon , Park, Dong Ho

Conference Paper Issue Date2023-10-28 View6

Heat shock protein 60 (HSP60) interact with glutaryl co-a dehydrogenase (GCDH)

Kang, Byoung Heon , None

Conference Paper Issue Date2013 View6

Hepatoprotective and antineoplastic properties of Protaetia brevitarsis larvae File

Lee, Ji-Eun , Jo, Da-Eun , Lee, An-Jung , Park, Hye-Kyung , Youn, Kumju , Yun, Eun-Young , Hwang, Jae-Sam , Jun, Mira , Kang, Byoung Heon

Article Issue Date2014-11 View7

HIF-1α/CypD Negative Regulation Accelerates Hypoxia-induced Cancer Metastasis

Park, Hye-Kyung , Kang, Byoung Heon

Conference Paper Issue Date2022-02-17 View7

Hsp60 regulation of tumor cell apoptosis File

Ghosh, Jagadish C. , Dohi, Takehiko , Kang, Byoung Heon , Altieri, Dario C.

Article Issue Date2008-02 View7

Inhibition studies on the nuclear inclusion protein a protease of turnip mosaic potyvirus C5

Kim, DH , Kang, Byoung Heon , Hwang, DC , Kim, SS , Kwon, TI , Choi, KY

Article Issue Date1996-12 View7

Interplay between TRAP1 and sirtuin-3 modulates mitochondrial respiration and oxidative stress to maintain stemness of glioma stem cells File

Park, Hye-Kyung , Hong, Jun-Hee , Oh, Young Taek , Kim, Sung Soo , Yin, Jinlong , Lee, An-Jung , Chae, Young Chan , Kim, Jong Heon , Park, Sung-Hye , Park, Chul-Kee , et al

Article Issue Date2019-04 View10

Loops of HIF1a and Cyclophilin D promote cancer netastasis through long-term ROS signaling.

Park, Hye-Kyung , Kang, Byoung Heon

Conference Paper Issue Date2020-10-08 View7

Microenvironment-adapted mitochondria promote metastasis

Park, Hye-Kyung , Kang, Byoung Heon

Conference Paper Issue Date2023-05-08 View5

Mitochondria adapted to the microenvironment of primary tumors promote cancer metastasis

Park, Hye-Kyung , Kang, Byoung Heon

Conference Paper Issue Date2023-06-16 View4

Mitochondria target therapy through inhibition TRAP1-IDH2 to treat relapse/refractory acute myeloid leukemia

Sung Hu , Park, Hye-Kyung , Kang, Byoung Heon

Conference Paper Issue Date2022-02-16 View7

Mitochondria target therapy through inhibition TRAP1-IDH2 to treat relapse/refractory AML

Hu, Sung , Park, Hye-Kyung , Kang, Byoung Heon

Conference Paper Issue Date2022-08-26 View11

Mitochondria-ER crosstalk and combination cancer therapy

Kang, Byoung Heon

Conference Paper Issue Date2012 View1

Mitochondria-targeted Hsp90 inhibitors as novel anticancer therapeutics

Kang, Byoung Heon

Conference Paper Issue Date2011 View1

Mitochondria-targeted Hsp90 inhibitors as novel anticancer therapeutics

Kang, Byoung Heon

Conference Paper Issue Date2010 View2

Mitochondrial Chaperone Protein, TRAP1 Modulates Mitochondrial Integrity by Regulating SSBP1(Single- Strand DNA Binding Protein 1).

Lee, JH , Kim, SY , Kang, Byoung Heon

Conference Paper Issue Date2022-08-26 View5

Mitochondrial Chaperone Protein, TRAP1 Modulates Mitochondrial Integrity by Regulating SSBP1(Single- Strand DNA Binding Protein 1).

Lee, JH , Kim, SY , Kang, Byoung Heon

Conference Paper Issue Date2022-02-16 View8

Mitochondrial chaperone TRAP1 and mitochondria-targeted inhibitor development

Kang, Byoung Heon

Conference Paper Issue Date2015-09-18 View3

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