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Kang, Byoung Heon
Cancer Biology Lab
Research Interests
  • Mitochondrial chaperones, cancer biology, cell death, metabolism, cancer stem cells, cancer therapeutics development

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Hepatoprotective and antineoplastic properties of Protaetia brevitarsis larvae

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Title
Hepatoprotective and antineoplastic properties of Protaetia brevitarsis larvae
Author
Lee, Ji-EunJo, Da-EunLee, An-JungPark, Hye-KyungYoun, KumjuYun, Eun-YoungHwang, Jae-SamJun, MiraKang, Byoung Heon
Issue Date
2014-11
Publisher
WILEY-BLACKWELL
Citation
ENTOMOLOGICAL RESEARCH, v.44, no.6, pp.244 - 253
Abstract
Protaetia brevitarsis larvae have been used as a traditional medicine to treat various liver diseases. Freeze-dried powder and solvent partitioned fractions of Protaetia brevitarsis larvae, in this study, were examined for hepatoprotective and antitumor activities in vivo and in vitro. Oral administration of the powder reduced signs of acute and chronic liver injuries in diethylnitrosamine-induced hepatotoxic mouse model. Various cancer cell types, but not normal primary hepatocytes, were killed by the hexane, ethyl acetate and butanol fractions, which were partitioned from larval extracts. Apoptosis and autophagy were primarily induced in cancer cells by hexane and ethyl acetate fractions, respectively, and can be the cytotoxic mechanisms of the fractions. Further analyses of the insect fractions could lead to identification of novel bioactive substances that can be exploited as therapeutics for various human liver diseases.
URI
https://scholarworks.unist.ac.kr/handle/201301/9411
URL
http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=84911986492
DOI
10.1111/1748-5967.12075
ISSN
1738-2297
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BIO_Journal Papers
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