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Kang, Byoung Heon
Cancer Biology Lab
Research Interests
  • Mitochondrial chaperones, cancer biology, cell death, metabolism, cancer stem cells, cancer therapeutics development

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Compartmentalized cancer drug discovery targeting mitochondrial Hsp90 chaperones

Cited 25 times inthomson ciCited 23 times inthomson ci
Title
Compartmentalized cancer drug discovery targeting mitochondrial Hsp90 chaperones
Author
Kang, Byoung HeonAltieri, D. C.
Issue Date
2009-10
Publisher
NATURE PUBLISHING GROUP
Citation
ONCOGENE, v.28, no.42, pp.3681 - 3688
Abstract
There is a plethora of attractive drug targets in cancer, but their therapeutic exploitation proved more difficult than expected, and only rarely truly successful. One possibility not often considered in drug discovery is that cancer signaling pathways are not randomly arranged in cells, but orchestrated in specialized subcellular compartments. The identification of heat shock protein-90 (Hsp90) chaperones in mitochondria of tumors, but not most normal tissues, provides an example of a compartmentalized network of cell survival, opening fresh prospects for novel, subcellularly targeted cancer drug discovery.
URI
https://scholarworks.unist.ac.kr/handle/201301/7086
URL
http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=70350568650
DOI
10.1038/onc.2009.227
ISSN
0950-9232
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BIO_Journal Papers
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