명경재
Myung, Kyungjae

명경재

Department of Biomedical Engineering(바이오메디컬공학과)

  • Center for Genomic Integrity
  • Website
Research Interests
Synthetic lethality;DNA Repair;DNA Recombination;ATAD5;PCNA;CRISPR;CRISPR Cas9;DNA Replication;DNA Damage Response;cancer;Aging;유전자 가위;합성치사이용 항암제 개발;DNA 손상복구;DNA 재조합 복구;DNA 복제;DNA 손상 신호 전달;암;노화
Lab Description
DNA is the building block for the genome and provides the blueprint for almost every aspect of life. DNA can be damaged by endogenous assaults such as replication errors, oxidative stress or by exogenous challenges such as radiation or toxic chemicals. Failure to repair such damage results in cell death or the accumulation of changes in DNA that can cause genetic diseases including cancers or can lead to premature aging.Research at the IBS Center for Genomic Integrity is concerned with the many DNA damage response and repair pathways that can sense and repair damaged DNA and signal to cells that there is an urgent problem to be addressed. We also study the link of these pathways to other parts of cellular metabolism, including DNA replication, cell cycle regulation or transcription.Our research spans many disciplines and techniques, including molecular, cell, chemical and structural biology, genetics, biochemistry and the use of animal models. Finally, we are interested in leveraging our research to develop small molecule modulators of DNA repair pathways as probes and to exploit vulnerabilities of tumors in therapeutic settings.

Oh, Jung-MinKang, YujinPark, JumiSung, YubinKim, DayoungSeo, YuriLee, EunARa, JaeSunAmarsanaa, EnkhzulPark, Young-Un , et al

Article Issue Date2023-06 View20

Ryu, EunjinHa, Na YoungJung, WoojaeYoo, JuyeongMyung, KyungjaeKang, Sukhyun

Article Issue Date2022-06 View12

Oh, Jung-MinMyung, Kyungjae

Article Issue Date2022-01 View19
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