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김철민
Ghim, Cheol-Min

김철민

물리학과

  • Physical Biology Biological Physics Lab.
  • Website
Research Interests
Control of complex networks;Nonequilibrium statistical physics;Stochastic cell biology;Biochemical information processing;Human microbiome;Ecological inference;Reinforcement learning;Network biology
Lab Description
The Ghim Lab seeks to find the “design” principles behind the networks of biological information processing. The networks encompass cellular metabolism, regulation of gene expression, cell-to-cell communication, and up to social and ecological interactions among individuals. The current focus of research is on:
• Control and exploitation of noise in gene expression• Resource allocation for coordinated metabolism• Causal inference in epidemic dynamics and ecological systems• Game theory in structured populations and reinforcement learning
The aim from biology side is to rationalize the efficiency and robustness of biological networks in the light of form-function duality. The other side of the coin is an effort to restore the precision and accuracy of biochemical information processing in e.g. synthetic biology or metabolic engineering up to its silicon-based counterpart. Both of these objectives are closely linked to the fundamental problems of equilibrium and nonequilibrium statistical mechanics on complex networks. Information theory and statistical physics are a major tool toward this end but the crux is still the rigorous biological realism.
Researcher ID Research Gate ORCiD Scopus Google Scholar
Previous
Memory-aware feedback enhances power in active information engines File

Bahng, Sehoon , Lee, Jae Sung , Ghim, Cheol-Min

Article Issue Date2025-11 View24
Intelligent Soft Matter: Towards Embodied Intelligence File

Baulin, Vladimir A. , Ghim, Cheol-Min , Hanczyc, Martin M.

Article Issue Date2025-06 View169
Fast product release requires active-site water dynamics in carbonic anhydrase File

Kim, Jin Kyun , Lim, Seon Woo , Jeong, Hannah , Lee, Cheol , Kim, Seoyoon , Son, Dong Woo , Kumar, Rajeev , Andring, Jacob T. , Lomelino, Carrie , Wierman, Jennifer L. , et al

Article Issue Date2025-05 View132
Enlightening the blind spot of the Michaelis-Menten rate law: The role of relaxation dynamics in molecular complex formation File

Chae, Junghun , Lim, Roktaek , Martin, Thomas L. P. , Ghim, Cheol-Min , Kim, Pan-Jun

Article Issue Date2025-01 View104
Generalized Michaelis-Menten rate law with time-varying molecular concentrations File File

Lim, Roktaek , Martin, Thomas L. P. , Chae, Junghun , Kim, WooJoong , Ghim, Cheol-Min , Kim, Pan-Jun

Article Issue Date2023-12 View207
The Boltzmann fair division for distributive justice File File

Park Ji-Won , Kim, Jaeup U. , Ghim, Cheol-Min , Kim, Chae Un

Article Issue Date2022-09 View198
Propagation of stochastic fluctuations in RNA polymerase abundance in constitutive gene expression File

Jang, Juneil , Ghim, Cheol-Min

Article Issue Date2022-01 View122
Backward simulation for inferring hidden biomolecular kinetic profiles File File

Chae, Junghun , Lim, Roktaek , Ghim, Cheol-Min , Kim, Pan-Jun

Article Issue Date2021-12 View113
Heterogeneity is not always a source of noise: Stochastic gene expression in regulatory heterozygote File

Jang, Juneil , Amblard, Francois , Ghim, Cheol-Min

Article Issue Date2021-10 View182
Cost-effective circadian mechanism: rhythmic degradation of circadian proteins spontaneously emerges without rhythmic post-translational regulation File File

Lim, Roktaek , Chae, Junghun , Somers, David E. , Kim, Pan-Jun , Ghim, Cheol-Min

Article Issue Date2021-07 View143
Photoacoustic Tomography Opening New Paradigms in Biomedical Imaging File

Yang, Joon Mo , Ghim, Cheol-Min

Article Issue Date2021-04 View136
Elucidating the role of metal ions in carbonic anhydrase catalysis File File

Kim, Jin Kyun , Lee, Cheol , Lim, Seon Woo , Andring, Jacob T. , Adhikari, Aniruddha , McKenna, Robert , Ghim, Cheol-Min , Kim, Chae Un

Article Issue Date2020-09 View221
Large-scale metabolic interaction network of the mouse and human gut microbiota File File

Lim, Roktaek , Cabatbat, Josephine Jill T. , Martin, Thomas L. P. , Kim, Haneul , Kim, Seunghyeon , Sung, Jaeyun , Ghim, Cheol-Min , Kim, Pan-Jun

Article Issue Date2020-06 View193
The KIAS-APCTP Winter School on Statistical Physics: 16 Years of Education

Ghim, Cheol-Min

Article Issue Date2019-04 View121
Effects of Zygosity on Stochastic Gene Expression of Diploid Cells File

Yang, Hyunmo , Jang, Juneil , Ghim, Cheol-Min

Article Issue Date2019-02 View116
Serum albumin and osmolality inhibit Bdellovibrio bacteriovorus predation in human serum File File

Im, Hansol , Son, Sangmo , Mitchell, Robert J. , Ghim, Cheol-Min

Article Issue Date2017-07 View153
세포 내 생체회로의 “설계” 원리 File

조정효 , 김철민

Article Issue Date2016-10 View121
Selected heterozygosity at cis-regulatory sequences increases the expression homogeneity of a cell population in humans File File

Sung, Min Kyung , Jang, Juneil , Lee, Kang Seon , Ghim, Cheol-Min , Choi, Jung Kyoon

Article Issue Date2016-07 View128
Hypothetical biomolecular probe based on a genetic switch with tunable symmetry and stability File File

Martyushenko, Nikolay , Johansen, Sigurd Haegen , Ghim, Cheol-Min , Almaas, Eivind

Article Issue Date2016-06 View142
Shedding Light on Microbial Predator-Prey Population Dynamics Using a Quantitative Bioluminescence Assay File

Im, Hansol , Kim, Dasol , Ghim, Cheol-Min , Mitchell, Robert J.

Article Issue Date2014-01 View155
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