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Ghim, Cheol-Min
Physical Biology & Biological Physics
Research Interests
  • Control of complex networks, Stochastic fluctuations in a cell, Biochemical information processing, Human microbiome, Ecological inference, Nonequilibrium active system

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Heterogeneity is not always a source of noise: Stochastic gene expression in regulatory heterozygote

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Title
Heterogeneity is not always a source of noise: Stochastic gene expression in regulatory heterozygote
Author
Jang, JuneilAmblard, FrancoisGhim, Cheol-Min
Issue Date
2021-10
Publisher
AMER PHYSICAL SOC
Citation
PHYSICAL REVIEW E, v.104, no.4, pp.044401
Abstract
Zygosity of diploid genome (i.e., degree to which two parental alleles of a gene have varied genetic sequences) adds another dimension to stochastic gene expression. The allelic imbalance in chromatin accessibility or divergence in regulatory sequences leads to fitness effects but the quantitative aspects thereof are largely left unexplored. We investigate diploid gene expression systems with homozygous (the same) and heterozygous (varied) combination of alleles in cis-regulatory sequences, not in structural gene loci, and characterize the zygosity-associated stochastic fluctuations in protein abundance. An emerging feat of heterozygosity is its counterintuitive capacity for genetic noise control. Especially when the noise is dominantly contributed to by the fluctuations in duty cycle ("reliability") rather than in process speed ("productivity") of gene expression machinery, its interallelic discrepancy acts to reduce the gene expression noise. These findings offer a novel insight into the rich repertoire of balancing selection enriched in the regulatory elements of immune response genes.
URI
https://scholarworks.unist.ac.kr/handle/201301/54828
URL
https://journals.aps.org/pre/abstract/10.1103/PhysRevE.104.044401
DOI
10.1103/PhysRevE.104.044401
ISSN
2470-0045
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PHY_Journal Papers
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