사진

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Ghim, Cheol-Min (김철민)

Department
Department of Physics(물리학과)
Website
http://pbbp.unist.ac.kr/
Lab
Physical Biology Biological Physics Lab. (이론생물물리 연구실)
Research Keywords
Control of complex networks, Nonequilibrium statistical physics, Stochastic cell biology, Biochemical information processing, Human microbiome, Ecological inference, Reinforcement learning, Network biology
Research Interests
The Ghim Lab seeks to find the “design” principles behind the networks of biological information processing. The networks encompass cellular metabolism, regulation of gene expression, cell-to-cell communication, and up to social and ecological interactions among individuals. The current focus of research is on:
• Control and exploitation of noise in gene expression• Resource allocation for coordinated metabolism• Causal inference in epidemic dynamics and ecological systems• Game theory in structured populations and reinforcement learning
The aim from biology side is to rationalize the efficiency and robustness of biological networks in the light of form-function duality. The other side of the coin is an effort to restore the precision and accuracy of biochemical information processing in e.g. synthetic biology or metabolic engineering up to its silicon-based counterpart. Both of these objectives are closely linked to the fundamental problems of equilibrium and nonequilibrium statistical mechanics on complex networks. Information theory and statistical physics are a major tool toward this end but the crux is still the rigorous biological realism.
This table browses all dspace content
Issue DateTitleAuthor(s)TypeViewAltmetrics
2022-01Propagation of stochastic fluctuations in RNA polymerase abundance in constitutive gene expressionJang, Juneil; Ghim, Cheol-MinARTICLE77 Propagation of stochastic fluctuations in RNA polymerase abundance in constitutive gene expression
2021-12Backward simulation for inferring hidden biomolecular kinetic profilesChae, Junghun; Lim, Roktaek; Ghim, Cheol-Min, et alARTICLE124 Backward simulation for inferring hidden biomolecular kinetic profiles
2021-10Heterogeneity is not always a source of noise: Stochastic gene expression in regulatory heterozygoteJang, Juneil; Amblard, Francois; Ghim, Cheol-MinARTICLE88 Heterogeneity is not always a source of noise: Stochastic gene expression in regulatory heterozygote
2021-07Cost-effective circadian mechanism: rhythmic degradation of circadian proteins spontaneously emerges without rhythmic post-translational regulationLim, Roktaek; Chae, Junghun; Somers, David E., et alARTICLE228 Cost-effective circadian mechanism: rhythmic degradation of circadian proteins spontaneously emerges without rhythmic post-translational regulation
2021-04Photoacoustic Tomography Opening New Paradigms in Biomedical ImagingYang, Joon Mo; Ghim, Cheol-MinARTICLE159 Photoacoustic Tomography Opening New Paradigms in Biomedical Imaging
2020-09Elucidating the role of metal ions in carbonic anhydrase catalysisKim, Jin Kyun; Lee, Cheol; Lim, Seon Woo, et alARTICLE301 Elucidating the role of metal ions in carbonic anhydrase catalysis
2020-06Large-scale metabolic interaction network of the mouse and human gut microbiotaLim, Roktaek; Cabatbat, Josephine Jill T.; Martin, Thomas L. P., et alARTICLE301 Large-scale metabolic interaction network of the mouse and human gut microbiota
2019-04The KIAS-APCTP Winter School on Statistical Physics: 16 Years of EducationGhim, Cheol-MinARTICLE172
2019-02Effects of Zygosity on Stochastic Gene Expression of Diploid CellsYang, Hyunmo; Jang, Juneil; Ghim, Cheol-MinARTICLE532 Effects of Zygosity on Stochastic Gene Expression of Diploid Cells
2017-07Serum albumin and osmolality inhibit Bdellovibrio bacteriovorus predation in human serumIm, Hansol; Son, Sangmo; Mitchell, Robert J., et alARTICLE1102 Serum albumin and osmolality inhibit Bdellovibrio bacteriovorus predation in human serum
2016-10세포 내 생체회로의 “설계” 원리조정효; 김철민ARTICLE817 세포 내 생체회로의 “설계” 원리
2016-07Selected heterozygosity at cis-regulatory sequences increases the expression homogeneity of a cell population in humansSung, Min Kyung; Jang, Juneil; Lee, Kang Seon, et alARTICLE946 Selected heterozygosity at cis-regulatory sequences increases the expression homogeneity of a cell population in humans
2016-06Hypothetical biomolecular probe based on a genetic switch with tunable symmetry and stabilityMartyushenko, Nikolay; Johansen, Sigurd Haegen; Ghim, Cheol-Min, et alARTICLE782 Hypothetical biomolecular probe based on a genetic switch with tunable symmetry and stability
2014-01Shedding Light on Microbial Predator-Prey Population Dynamics Using a Quantitative Bioluminescence AssayIm, Hansol; Kim, Dasol; Ghim, Cheol-Min, et alARTICLE1247 Shedding Light on Microbial Predator-Prey Population Dynamics Using a Quantitative Bioluminescence Assay
2012-02Rewiring carbon catabolite repression for microbial cell factoryVinuselvi, Parisutham; Kim, Min Kyung; Lee, Sung Kuk, et alARTICLE1327 Rewiring carbon catabolite repression for microbial cell factory
2011-03Engineering microorganisms for biofuel productionParisutham, Vinuselvi; Park, Jung Min; Lee, Jae Myung, et alARTICLE1105 Engineering microorganisms for biofuel production
2011-03부품소재은행이재명; 김태성; 김철민, et alARTICLE608
2011-01Microbial linguistics: perspectives and applications of microbial cell-to-cell communicationMitchell, Robert J.; Lee, Sung Kuk; Kim, Taesung, et alARTICLE1264 Microbial linguistics: perspectives and applications of microbial cell-to-cell communication
2010-07The art of reporter proteins in science: past, present and future applicationsGhim, Cheol-Min; Lee, Sung Kuk; Takayama, Shuichi, et alARTICLE1047 The art of reporter proteins in science: past, present and future applications
2010-01Synthetic Biology for Biofuels: Building Designer Microbes from the ScratchGhim, Cheol-Min; Kim, Taesung; Mitchell, Robert J., et alARTICLE1214 Synthetic Biology for Biofuels: Building Designer Microbes from the Scratch

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