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김하진
Kim, Hajin

김하진

바이오메디컬공학과

  • Single Molecule Biophysics Lab.
  • Website
Research Interests
Biophysics;biological Motors;Single Molecule Dynamics;fluorescence Spectroscopy;molecular motors;Genome Imaging;Chromatin Dynamics;Super-Resolution Microscopy;Single Molecule Mechanobiology
Lab Description
We look at “Life”, molecule by molecule. Single molecule approaches to biology and biophysics reveal unforeseen details about the building blocks of biology. From these, we can understand the role of fluctuations and the interplay of molecules, to open new insights into the functioning of the biomolecules. These insights can provide novel strategies toward biomedical problems as well as answers to scientific questions. We develop and combine cutting-edge single molecule and single cell techniques to solve important problems in biological science, including the organization and dynamics of chromosomes, biomolecular recognition/assembly, molecular machinery working on nucleic acids, and intrinsically disordered proteins. Our study requires cross-disciplinary efforts from biologists, physicists, chemists, and engineering scientists and we pursue collaborations with groups from diverse scientific disciplines. One of our major interests is to uncover the molecular level principles that govern the spatiotemporal organization of chromatin and its epigenetic control for regulating DNA repair and gene expression, eventually determining the fate of the cell.
Researcher ID Research Gate ORCiD Scopus Google Scholar
Previous
Live genome imaging by CRISPR engineering: progress and problems File

Park, Eui-Jin , Kim, Hajin

Article Issue Date2025-07 View50
Fast and accurate multi-bacterial identification using cleavable and FRET-based peptide nucleic acid probes File

Kim, Sungho , Hyun, Hwi , Im, Jae-Kyeong , Lee, Min Seok , Koh, Hwasoo , Kang, Donghoon , Nho, Si-Hyeong , Kang, Joo H. , Kwon, Taejoon , Kim, Hajin

Article Issue Date2025-03 View214
Dynamics of nucleosomes and chromatin fibers revealed by single-molecule measurements File

Nho, Sihyeong , Kim, Hajin

Article Issue Date2025-01 View84
One-hit kill: On the inactivation of RNA viruses by ultraviolet (UV)-C-induced genomic damage File

Park, Hyun , Shin, Go Woon , Lee, Sang Min , Jeong, Gyu Won , Kim, Hui Young , Kim, Hajin , Choi, Hyun Woo , Lee-Kwon, Whaseon , Kwon, Hyug Moo

Article Issue Date2024-08 View127
ssDNA reeling is an intermediate step in the reiterative DNA unwinding activity of the WRN-1 helicase File File

Le, Son Truong , Choi, Seoyun , Lee, Seung-Won , Kim, Hajin , Ahn, Byungchan

Article Issue Date2023-09 View147
DNA polymerase theta-mediated repair of high LET radiation-induced complex DNA double-strand breaks File File

Yi, Geunil , Sung, Yubin , Kim, Chanwoo , Ra, Jae Sun , Hirakawa, Hirokazu , Kato, Takamitsu A. , Fujimori, Akira , Kim, Hajin , Takata, Kei-ichi

Article Issue Date2023-03 View133
Quantitative fluorescence in situ hybridization (FISH) of magnetically confined bacteria enables early detection of human bacteremia File

Lee, Min Seok , Hyun, Hwi , Park, Inwon , Kim, Sungho , Jang, Dong-Hyun , Kim, Seonghye , Im, Jae-Kyeong , Kim, Hajin , Lee, Jae Hyuk , Kwon, Taejoon , et al

Article Issue Date2022-01 View230
Visualizing Live Chromatin Dynamics through CRISPR-Based Imaging Techniques File File

Chaudhary, Narendra , Im, Jae-Kyeong , Nho, Si-Hyeong , Kim, Hajin

Article Issue Date2021-09 View158
Analysis of Porcine Model of Fecal-Induced Peritonitis Reveals the Tropism of Blood Microbiome File File

Hyun, Hwi , Lee, Min Seok , Park, Inwon , Ko, Hwa Soo , Yun, Seongmin , Jang, Dong-Hyun , Kim, Seonghye , Kim, Hajin , Kang, Joo H. , Lee, Jae Hyuk , et al

Article Issue Date2021-08 View193
Background-suppressed live visualization of genomic loci with an improved CRISPR system based on a split fluorophore File

Chaudhary, Narendra , Nho, Si-Hyeong , Cho, Hayoon , Gantumur, Narangerel , Ra, Jae Sun , Myung, Kyungjae , Kim, Hajin

Article Issue Date2020-09 View178
The dynamic landscape of transcription initiation in yeast mitochondria File File

Sohn, Byeong-Kwon , Basu, Urmimala , Lee, Seung-Won , Cho, Hayoon , Shen, Jiayu , Deshpande, Aishwarya , Johnson, Laura C. , Das, Kalyan , Patel, Smita S. , Kim, Hajin

Article Issue Date2020-08 View93
Tonicity-responsive enhancer-binding protein promotes stemness of liver cancer and cisplatin resistance File File

Lee, Jun Ho , Suh, Jae Hee , Kang, Hyun Je , Choi, Soo Youn , Jung, Seok Won , Lee-Kwon, Whaseon , Park, Soo-Ah , Kim, Hajin , Ye, Byeong Jin , Yoo, Eun Jin , et al

Article Issue Date2020-08 View151
The C-terminal tail of the yeast mitochondrial transcription factor Mtf1 coordinates template strand alignment, DNA scrunching and timely transition into elongation File File

Basu, Urmimala , Lee, Seung-Won , Deshpande, Aishwarya , Shen, Jiayu , Sohn, Byeong-Kwon , Cho, Hayoon , Kim, Hajin , Patel, Smita S.

Article Issue Date2020-03 View106
Increased Confinement and Polydispersity of STIM1 and Orai1 after Ca2+ Store Depletion File

Qin, Xianan , Liu, Lei , Lee, Sang Kwon , Alsina, Adolfo , Liu, Teng , Wu, Chao , Park, Hojeong , Yu, Chenglong , Kim, Hajin , Chu, Jun , et al

Article Issue Date2020-01 View133
Molecular characteristics of reiterative DNA unwinding by the Caenorhabditis elegans RecQ helicase File File

Choi, Seoyun , Lee, Seung-Won , Kim, Hajin , Ahn, Byungchan

Article Issue Date2019-10 View131
Subtyping of influenza A H1N1 virus using a label-free electrochemical biosensor based on the DNA aptamer targeting the stem region of HA protein File

Bhardwaj, Jyoti , Chaudhary, Narendra , Kim, Hajin , Jang, Jaesung

Article Issue Date2019-08 View118
Regulation of PCNA cycling on replicating DNA by RFC and RFC-like complexes File

Kang, Mi-Sun , Ryu, Eunjin , Lee, Seung-Won , Park, Jieun , Ha, Na Young , Ra, Jae Sun , Kim, Yeong Jae , Kim, Jinwoo , Adbel-Rahman, Mohamed , Park, Su Hyung , et al

Article Issue Date2019-06 View116
Sequence-dependent DNA condensation as a driving force of DNA phase separation File File

Kang, Hyunju , Yoo, Jejoong , Sohn, Byeong-Kwon , Lee, Seung-Won , Lee, Hong Soo , Ma, Wenjie , Kee, Jung-Min , Aksimentiev, Aleksei , Kim, Hajin

Article Issue Date2018-10 View262
Evolution of protein-coupled RNA dynamics during hierarchical assembly of ribosomal complexes File File

Abeysirigunawardena, Sanjaya C. , Kim, Hajin , Lai, Jonathan , Ragunathan, Kaushik , Rappe, Mollie C. , Luthey-Schulten, Zaida , Ha, Taekjip , Woodson, Sarah A.

Article Issue Date2017-09 View200
Integrative Approach toward Uncovering the Origin of Photoluminescence in Dual Heteroatom-Doped Carbon Nanodots File

Choi, Yuri , Kang, Byungkyun , Lee, Jooyong , Kim, Sunghu , Kim, Gyeong Tae , Kang, Hyunju , Lee, Bo Ram , Kim, Hajin , Shim, Sang-Hee , Lee, Geunsik , et al

Article Issue Date2016-10 View255
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