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김재익
Kim, Jae-Ick

김재익

Department of Biological Sciences(생명과학과)

  • Neural Circuit and Neurodegenerative Disease Lab.
  • Website
Research Interests
Modulatory neurons;Dopamine neurons;Neurotransmitter co-transmission;Normal and pathological ageing;Parkinson's disease;Alzheimer's disease;Neurodegenerative diseases;Basal ganglia microcircuits;파킨슨병;알츠하이머병;퇴행성뇌질환;기저핵 미세회로;조절성 신경세포;도파민 신경세포;신경전달물질 동시전달;정상 및 병적 노화
Lab Description
Basal ganglia are a group of subcortical nuclei including striatum, globus pallidus, and substantia nigra. The major function of this system is to integrate both sensory and motor information, eventually leading to motor coordination, action selection, and reward-related learning, most of which are severely impaired in Parkinson’s disease. Our long-term goal is to identify the essential modification of basal ganglia circuitry contributing to the development of neurodegenerative diseases. Taking advantage of multi-disciplinary approaches including whole-cell patch clamp, single-unit recording, two-photon laser microscopy, super-resolution imaging, optogenetics, and behavioral assays, we also aim to identify pre-symptomatic physiological markers for Parkinson’s disease.
Researcher ID Research Gate ORCiD Scopus Google Scholar
Previous
The dopamine analogue CA140 alleviates AD pathology, neuroinflammation, and rescues synaptic/cognitive functions by modulating DRD1 signaling or directly binding to Abeta File File

Chae, Sehyun , Lee, Hyun-ju , Lee, Ha-Eun , Kim, Jieun , Jeong, Yoo Joo , Lin, Yuxi , Kim, Hye Yun , Leriche, Geofray , Ehrlich, Rachel S. , Lingl, Sascha Castro , et al

Article Issue Date2024-08 View17
Reelin and APP Cooperatively Modulate Dendritic Spine Formation In Vitro and In Vivo File File

Lee, Hyun-ju , Park, Jin-Hee , Trotter, Justin H. , Maher, James N. , Keenoy, Kathleen E. , Jang, You Mi , Lee, Youngeun , Kim, Jae-Ick , Weeber, Edwin J. , Hoe, Hyang-Sook

Article Issue Date2023-03 View38
L-Type Ca2+ Channel Inhibition Rescues the LPS-Induced Neuroinflammatory Response and Impairments in Spatial Memory and Dendritic Spine Formation File File

Kim, Jieun , Jeon, Seong Gak , Jeong, Ha-Ram , Park, HyunHee , Kim, Jae-Ick , Ho, Hyang-Sook

Article Issue Date2022-11 View28
High-throughput high-dynamic range imaging by spatiotemporally structured illumination File File

Woo, Taeseong , Kim, Hye Yun , Kim, Su Yeon , Hwang, Byungjae , Ahn, Cheolwoo , Kwon, Seok-Kyu , Kim, Jae-Ick , Park, Jung-Hoon

Article Issue Date2022-10 View31
Adaptive cellular response of the substantia nigra dopaminergic neurons upon age-dependent iron accumulation File

Kwon, Kujin , Cho, Hwapyeong , Lee, Soyeon , Cho, Eun Jeong , Yu, Weonjin , Kok, Catherine Yen Li , Je, Hyunsoo Shawn , Kim, Jae-Ick , Cho, Hyungjoon , Kwon, Taejoon

Article Issue Date2022-09 View92
Motor Impairments and Dopaminergic Defects Caused by Loss of Leucine-Rich Repeat Kinase Function in Mice File

Huang, Guodong , Bloodgood, Daniel W. , Kang, Jongkyun , Shahapal, Anu , Chen, Phoenix , Kaganovsky, Konstantin , Kim, Jae-Ick , Ding, Jun B. , Shen, Jie

Article Issue Date2022-06 View22
mtIF3 is locally translated in axons and regulates mitochondrial translation for axonal growth File File

Lee, Soyeon , Park, Dongkeun , Lim, Chunghun , Kim, Jae-Ick , Min, Kyung-Tai

Article Issue Date2022-01 View28
O-GlcNAcylation in health and neurodegenerative diseases File

Lee, Byeong Eun , Suh, Pann-Ghill , Kim, Jae-Ick

Article Issue Date2021-11 View35
Vernicia fordii (Hemsl.) Airy Shaw extract stimulates insulin secretion in pancreatic beta-cells and improves insulin sensitivity in diabetic mice File

Hyun, Jimin , Park, Mi Hyeon , Lee, Yo Han , Lee, Youngeun , Jeong, Su Ji , Choi, Sun Sil , Khim, Keon Woo , Eom, Hye Jin , Hur, Jin-Hoe , Park, Chan Young , et al

Article Issue Date2021-10 View44
The role of phospholipase C in gabaergic inhibition and its relevance to epilepsy File File

Kim, Hye Yun , Suh, Pann-Ghill , Kim, Jae-Ick

Article Issue Date2021-03 View31
O-GlcNAcylation regulates dopamine neuron function, survival and degeneration in Parkinson disease File

Lee, Byeong Eun , Kim, Hye Yun , Kim, Hyun-Jin , Jeong, Hyeongsun , Kim, Byung-Gyu , Lee, Ha-Eun , Lee, Jieun , Kim, Han Byeol , Lee, Seung Eun , Yang, Yong Ryoul , et al

Article Issue Date2020-12 View34
The novel DYRK1A inhibitor KVN93 regulates cognitive function, amyloid-beta pathology, and neuroinflammation File

Lee, Hyun-ju , Woo, Hanwoong , Lee, Ha-Eun , Jeon, Hyongjun , Ryu, Ka-Young , Nam, Jin han , Jeon, Seong Gak , Park, HyunHee , Lee, Ji-Soo , Han, Kyung-Min , et al

Article Issue Date2020-11 View32
Sequentially induced motor neurons from human fibroblasts facilitate locomotor recovery in a rodent spinal cord injury model File File

Lee, Hyunah , Lee, Hye Yeong , Lee, Byeong Eun , Gerovska, Daniela , Park, Soo Yong , Zaehres, Holm , Araúzo-Bravo, Marcos J , Kim, Jae-Ick , Ha, Yoon , Schöler, Hans R , et al

Article Issue Date2020-06 View32
Transient cAMP elevation during systems consolidation enhances remote contextual fear memory File

Lee, Jaehyun , Lee, Hye-Ryeon , Kim, Jae-Ick , Baek, Jinhee , Jang, Eun-Hae , Lee, Jihye , Kim, Myeongwon , Lee, Ro Un , Kim, Somi , Park, Pojeong , et al

Article Issue Date2020-03 View28
Direct-write printing for producing biomimetic patterns with self-aligned neurites File

Noh, Sujin , Kim, Kyungha , Kim, Jae-Ick , Shin, Jung Hwal , Kang, Hyun-Wook

Article Issue Date2020-03 View32
Deletion of PLCγ1 in GABAergic neurons increases seizure susceptibility in aged mice File File

Kim, Hye Yun , Yang, Yong Ryoul , Hwang, Hongik , Lee, Ha-Eun , Jang, Hyun-Jun , Kim, Jeongyeon , Yang, Esther , Kim, Hyun , Rhim, Hyewhon , Suh, Pann-Ghill , et al

Article Issue Date2019-11 View27
The THO Complex Coordinates Transcripts for Synapse Development and Dopamine Neuron Survival File

Maeder, Celine I. , Kim, Jae-Ick , Liang, Xing , Kaganovsky, Konstantin , Shen, Ao , Li, Qin , Li, Zhaoyu , Wang, Sui , Xu, X. Z. Shawn , Li, Jin Billy , et al

Article Issue Date2018-09 View22
β-Adrenergic signaling is required for the induction of a labile state during memory reconsolidation File

Lim, Chae-Seok , Kim, Jae-Ick , Kwak, Chuljung , Lee, Jaehyun , Jang, Eun Hae , Oh, Jihae , Kaang, Bong-Kiun

Article Issue Date2018-07 View40
TGF-β Signaling in Dopaminergic Neurons Regulates Dendritic Growth, Excitatory-Inhibitory Synaptic Balance, and Reversal Learning File File

Luo, Sarah X. , Timbang, Leah , Kim, Jae-Ick , Shang, Yulei , Sandoval, Kadellyn , Tang, Amy A. , Whistler, Jennifer L. , Ding, Jun B. , Huang, Eric J.

Article Issue Date2016-12 View33
The Brain-Enriched MicroRNA miR-9-3p Regulates Synaptic Plasticity and Memory File

Sim, Su-Eon , Lim, Chae-Seok , Kim, Jae-Ick , Seo, Daekwan , Chun, Heejung , Yu, Nam-Kyung , Lee, Jaehyun , Kang, SukJae Joshua , Ko, Hyoung-Gon , Choi, Jun-Hyeok , et al

Article Issue Date2016-08 View45
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