Transient cAMP elevation during systems consolidation enhances remote contextual fear memory

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Title
Transient cAMP elevation during systems consolidation enhances remote contextual fear memory
Author
Lee, JaehyunLee, Hye-RyeonKim, Jae-IckBaek, JinheeJang, Eun-HaeLee, JihyeKim, MyeongwonLee, Ro UnKim, SomiPark, PojeongKaang, Bong-Kiun
Issue Date
2020-03
Publisher
Academic Press
Citation
NEUROBIOLOGY OF LEARNING AND MEMORY, v.169, pp.107171
Abstract
Memory is stored in our brains over a temporally graded transition. With time, recently formed memories are transformed into remote memories for permanent storage; multiple brain regions, such as the hippocampus and neocortex, participate in this process. In this study, we aimed to understand the molecular mechanism of systems consolidation of memory and to investigate the brain regions that contribute to this regulation. We first carried out a contextual fear memory test using a transgenic mouse line, which expressed exogenously-derived Aplysia octopamine receptors in the forebrain region, such that, in response to octopamine treatment, cyclic adenosine monophosphate (cAMP) levels could be transiently elevated. From this experiment, we revealed that transient elevation of cAMP levels in the forebrain during systems consolidation led to an enhancement in remote fear memory and increased miniature excitatory synaptic currents in layer II/III of the anterior cingulate cortex (ACC). Furthermore, using an adeno-associated-virus-driven DREADD system, we investigated the specific regions in the forebrain that contribute to the regulation of memory transfer into long-term associations. Our results implied that transient elevation of cAMP levels was induced chemogenetically in the ACC, but not in the hippocampus, and showed a significant enhancement of remote memory. This finding suggests that neuronal activation during systems consolidation through the elevation of cAMP levels in the ACC contributes to remote memory enhancement.
URI
https://scholarworks.unist.ac.kr/handle/201301/31140
URL
https://www.sciencedirect.com/science/article/pii/S1074742720300150?via%3Dihub
DOI
10.1016/j.nlm.2020.107171
ISSN
1074-7427
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