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Gartner, Anton (GartnerAnton)

Department
Department of Biological Sciences(생명과학과)
Website
http://sls.unist.ac.kr/en/_people/facultyview.asp?cate=3&seq=8062&email=tgartner@unist.ac.kr
Lab
DNA Damage Response and Genetic Toxicology (유전체 손상 반응 및 독성물)
Research Keywords
DNA Damage Response, Genetic Toxicology, DNA repair, mutagenesis, genetics
Research Interests
My Research focuses on understanding basic mechanisms of mutagenesis and on fail-safe mechanisms that ensure faithful genome maintenance and the elimination of compromised cells by programmed cell death. We mainly use C. elegans as an invertebrate model organism and employs advanced genetics, genomics, cell biology and next generation sequencing based approaches. Despite of its simplicity, C. elegans is a multicellular organism that shares many fundamental genetic programs with humans. Thus, many results obtained in the C. elegans system are likely to be applicable to mammalian systems. Our studies on C. elegans are facilitated by the simplicity of the organism at the developmental and anatomical level, by the ease of its maintenance, as well as by the power of forward and reverse genetic procedures. At the same time, we use mammalian cells to translate our insights gained from the invertebrate model. Our studies are relevant for understanding fundamental mechanisms leading to cancer formation and also aimed to better understand and more effectively use a range of agents commonly used for cancer therapy. We are engaged in multiple national and international collaborations and are currently transferring our lab from Scotland to Korea.
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Issue DateTitleAuthor(s)TypeViewAltmetrics
2021-01Bub1 kinase in the regulation of mitosisKim, Taekyung; Gartner, AntonARTICLE10 Bub1 kinase in the regulation of mitosis
2020-11Ewing sarcoma protein promotes dissociation of poly(ADP-ribose) polymerase 1 from chromatinLee, Seon-gyeong; Kim, Namwoo; Kim, Su-min, et alARTICLE69 Ewing sarcoma protein promotes dissociation of poly(ADP-ribose) polymerase 1 from chromatin
2020-11Analysis of mutational signatures in C. elegans: Implications for cancer genome analysisMeier, Bettina; Volkova, Nadezda V.; Gerstung, Moritz, et alARTICLE37 Analysis of mutational signatures in C. elegans: Implications for cancer genome analysis
2020-10Human ANKLE1 Is a Nuclease Specific for Branched DNASong, Junfang; Freeman, Alasdair D. J.; Knebel, Axel, et alARTICLE71 Human ANKLE1 Is a Nuclease Specific for Branched DNA
2020-05Mutational signatures are jointly shaped by DNA damage and repairVolkova, Nadezda V.; Meier, Bettina; Gonzalez-Huici, Vctor, et alARTICLE189 Mutational signatures are jointly shaped by DNA damage and repair
2018-06The conserved LEM-3/Ankle1 nuclease is involved in the combinatorial regulation of meiotic recombination repair and chromosome segregation in Caenorhabditis elegansHong, Ye; Velkova, Maria; Silva, Nicola, et alARTICLE251 The conserved LEM-3/Ankle1 nuclease is involved in the combinatorial regulation of meiotic recombination repair and chromosome segregation in Caenorhabditis elegans
2018-05Mutational signatures of DNA mismatch repair deficiency in C. elegans and human cancersMeier, Bettina; Volkova, Nadezda V.; Hong, Ye, et alARTICLE251 Mutational signatures of DNA mismatch repair deficiency in C. elegans and human cancers
2018-02LEM-3 is a midbody-tethered DNA nuclease that resolves chromatin bridges during late mitosisHong, Ye; Sonneville, Remi; Wang, Bin, et alARTICLE304 LEM-3 is a midbody-tethered DNA nuclease that resolves chromatin bridges during late mitosis
2018-01Mutations in Caenorhabditis elegans neuroligin-like glit-1, the apoptosis pathway and the calcium chaperone crt-1 increase dopaminergic neurodegeneration after 6-OHDA treatmentOffenburger, Sarah-Lena; Jongsma, Elisabeth; Gartner, AntonARTICLE248 Mutations in Caenorhabditis elegans neuroligin-like glit-1, the apoptosis pathway and the calcium chaperone crt-1 increase dopaminergic neurodegeneration after 6-OHDA treatment
2018-016-OHDA-induced dopaminergic neurodegeneration in Caenorhabditis elegans is promoted by the engulfment pathway and inhibited by the transthyretin-related protein TTR-33Offenburger, Sarah-Lena; Ho, Xue Yan; Tachie-Menson, Theresa, et alARTICLE270 6-OHDA-induced dopaminergic neurodegeneration in Caenorhabditis elegans is promoted by the engulfment pathway and inhibited by the transthyretin-related protein TTR-33
2018Biochemical and Structural Properties of Fungal Holliday Junction-Resolving EnzymesLiu, Yijin; Freeman, Alasdair; Declais, Anne-Cecile, et alARTICLE237 Biochemical and Structural Properties of Fungal Holliday Junction-Resolving Enzymes
20186-hydroxydopamine (6-OHDA) Oxidative Stress Assay for Observing Dopaminergic Neuron Loss in Caenorhabditis elegansOffenburger, Sarah-Lena; Gartner, AntonARTICLE150 6-hydroxydopamine (6-OHDA) Oxidative Stress Assay for Observing Dopaminergic Neuron Loss in Caenorhabditis elegans
2017-12Caenorhabditis elegans BUB-3 and SAN-1/MAD3 Spindle Assembly Checkpoint Components Are Required for Genome Stability in Response to Treatment with Ionizing RadiationBertolini, Simone; Wang, Bin; Meier, Bettina, et alARTICLE213 Caenorhabditis elegans BUB-3 and SAN-1/MAD3 Spindle Assembly Checkpoint Components Are Required for Genome Stability in Response to Treatment with Ionizing Radiation
2017-08A Role for the Nonsense-Mediated mRNA Decay Pathway in Maintaining Genome Stability in Caenorhabditis elegansGonzalez-Huici, Victor; Wang, Bin; Gartner, AntonARTICLE219 A Role for the Nonsense-Mediated mRNA Decay Pathway in Maintaining Genome Stability in Caenorhabditis elegans
2017-07Multi-omics Analyses of Starvation Responses Reveal a Central Role for Lipoprotein Metabolism in Acute Starvation Survival in C. elegansHarvald, Eva Bang; Sprenger, Richard R.; Dall, Kathrine Braendgaard, et alARTICLE214 Multi-omics Analyses of Starvation Responses Reveal a Central Role for Lipoprotein Metabolism in Acute Starvation Survival in C. elegans
2017-06Comparative genetic, proteomic and phosphoproteomic analysis of C. elegans embryos with a focus on ham-1/STOX and pig-1/MELK in dopaminergic neuron developmentOffenburger, Sarah-Lena; Bensaddek, Dalila; Murillo, Alejandro Brenes, et alARTICLE210 Comparative genetic, proteomic and phosphoproteomic analysis of C. elegans embryos with a focus on ham-1/STOX and pig-1/MELK in dopaminergic neuron development
2017-04CUL-2(LRR-1) and UBXN-3 drive replisome disassembly during DNA replication termination and mitosisSonneville, Remi; Moreno, Sara Priego; Knebel, Axel, et alARTICLE210 CUL-2(LRR-1) and UBXN-3 drive replisome disassembly during DNA replication termination and mitosis
2017-01A SUMO-Dependent Protein Network Regulates Chromosome Congression during Oocyte MeiosisPelisch, Federico; Tammsalu, Triin; Wang, Bin, et alARTICLE243 A SUMO-Dependent Protein Network Regulates Chromosome Congression during Oocyte Meiosis
2016-09E4 ligase-specific ubiquitination hubs coordinate DNA double-strand-break repair and apoptosisAckermann, Leena; Schell, Michael; Pokrzywa, Wojciech, et alARTICLE210 E4 ligase-specific ubiquitination hubs coordinate DNA double-strand-break repair and apoptosis
2016-08Deep Proteome Analysis Identifies Age-Related Processes in C. elegansNarayan, Vikram; Ly, Tony; Pourkarimi, Ehsan, et alARTICLE214 Deep Proteome Analysis Identifies Age-Related Processes in C. elegans

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