Kim, Jae-Ick (김재익)

Department

Department of Biological Sciences(생명과학과)

Website

https://jikimlab.imweb.me/

Lab

Neural Circuit and Neurodegenerative Disease Lab. (신경회로 및 퇴행성뇌질환 연구실)

Research Keywords

파킨슨병, 알츠하이머병, 퇴행성뇌질환, 기저핵 미세회로, 조절성 신경세포, 도파민 신경세포, 신경전달물질 동시전달, 정상 및 병적 노화, Modulatory neurons, Dopamine neurons, Neurotransmitter co-transmission, Normal and pathological ageing, Parkinson's disease, Alzheimer's disease, Neurodegenerative diseases, Basal ganglia microcircuits

Research Interests

Basal ganglia are a group of subcortical nuclei including striatum, globus pallidus, and substantia nigra. The major function of this system is to integrate both sensory and motor information, eventually leading to motor coordination, action selection, and reward-related learning, most of which are severely impaired in Parkinson’s disease. Our long-term goal is to identify the essential modification of basal ganglia circuitry contributing to the development of neurodegenerative diseases. Taking advantage of multi-disciplinary approaches including whole-cell patch clamp, single-unit recording, two-photon laser microscopy, super-resolution imaging, optogenetics, and behavioral assays, we also aim to identify pre-symptomatic physiological markers for Parkinson’s disease.