Myung, Kyungjae (명경재)

Department

Department of Biomedical Engineering(바이오메디컬공학과)

Website

http://cgi.ibs.re.kr/html/cgi_en

Lab

Center for Genomic Integrity (분자세포생물학실험실)

Research Keywords

유전자 가위, 합성치사이용 항암제 개발, DNA 손상복구, DNA 재조합 복구, DNA 복제, DNA 손상 신호 전달, 암, 노화, Synthetic lethality, DNA Repair, DNA Recombination, ATAD5, PCNA, CRISPR, CRISPR Cas9, DNA Replication, DNA Damage Response, cancer, Aging

Research Interests

DNA is the building block for the genome and provides the blueprint for almost every aspect of life. DNA can be damaged by endogenous assaults such as replication errors, oxidative stress or by exogenous challenges such as radiation or toxic chemicals. Failure to repair such damage results in cell death or the accumulation of changes in DNA that can cause genetic diseases including cancers or can lead to premature aging.Research at the IBS Center for Genomic Integrity is concerned with the many DNA damage response and repair pathways that can sense and repair damaged DNA and signal to cells that there is an urgent problem to be addressed. We also study the link of these pathways to other parts of cellular metabolism, including DNA replication, cell cycle regulation or transcription.Our research spans many disciplines and techniques, including molecular, cell, chemical and structural biology, genetics, biochemistry and the use of animal models. Finally, we are interested in leveraging our research to develop small molecule modulators of DNA repair pathways as probes and to exploit vulnerabilities of tumors in therapeutic settings.