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Park, Jiyoung
Molecular Metabolism Laboratory (MML)
Research Interests
  • Obesity, diabetes, adipose tissue, cancer, cancer-associated adipocyte, dermal adipocyte, metabolic memory

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Hyperglycemia as a risk factor for cancer progression

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Title
Hyperglycemia as a risk factor for cancer progression
Author
Ryu, Tae YoungPark, JiyoungScherer, Philipp E.
Issue Date
2014-10
Publisher
대한당뇨병학회
Citation
DIABETES AND METABOLISM JOURNAL, v.38, no.5, pp.330 - 336
Abstract
As the prevalence of diabetes mellitus is substantially increasing worldwide, associated diseases such as renal failure, cardiovascular diseases, fatty liver, and cancers have also increased. A number of cancers such as pancreatic, liver, breast, and female reproductive cancers have shown an increased prevalence and a higher mortality rate in diabetic patients compared to healthy subjects. Thus, this suggests an association between diabetes, especially type 2 diabetes and cancer incidence and progression. Recent studies have suggested that hyperinsulinemia, chronic inflammation and hyperglycemia, all frequently seen in diabetics, may lead to increased tumor growth; the underlying molecular mechanisms of this association are not fully understood. In particular, chronic hyperglycemic episodes could serve as a direct or indirect mediator of the increase in tumor cell growth. Here, we will discuss our current understanding how hyperglycemia and cancer risk may be linked, and what the implications are for the treatment of diabetic cancer patients.
URI
https://scholarworks.unist.ac.kr/handle/201301/9241
DOI
10.4093/dmj.2014.38.5.330
ISSN
2233-6079
Appears in Collections:
BIO_Journal Papers
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