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- Park, Cheol-Min
- Synthetic and Medicinal Chemistry Lab.
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Non-peptidic small molecule inhibitors of XIAP
- Author(s)
- Park, Cheol-Min, Sun, CH, Olejniczak, ET, Wilson, AE, Meadows, RP, Betz, SF, Elmore, SW, Fesik, SW
- Issued Date
- 2005-02
- Citation
- BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, v.15, no.3, pp.771 - 775
- Abstract
- Non-peptidic small molecule SMAC mimetics were designed and synthesized that bind to the BIR3 domain of XIAP using structure-based design. Substituted five-membered heterocycles such as thiazoles and imidazoles were identified that serve as replacements for peptide fragments of the lead.
- Publisher
- PERGAMON-ELSEVIER SCIENCE LTD
- ISSN
- 0960-894X
- Keyword (Author)
- SMAC mimetics, XIAP inhibitors
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