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Park, Cheol-Min
Synthetic & Medicinal Chemistry Lab
Research Interests
  • Organic synthesis, medicinal chemistry, chemical biology

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Non-peptidic small molecule inhibitors of XIAP

Cited 41 times inthomson ciCited 43 times inthomson ci
Title
Non-peptidic small molecule inhibitors of XIAP
Author
Park, Cheol-MinSun, CHOlejniczak, ETWilson, AEMeadows, RPBetz, SFElmore, SWFesik, SW
Issue Date
2005-02
Publisher
PERGAMON-ELSEVIER SCIENCE LTD
Citation
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, v.15, no.3, pp.771 - 775
Abstract
Non-peptidic small molecule SMAC mimetics were designed and synthesized that bind to the BIR3 domain of XIAP using structure-based design. Substituted five-membered heterocycles such as thiazoles and imidazoles were identified that serve as replacements for peptide fragments of the lead.
URI
https://scholarworks.unist.ac.kr/handle/201301/8563
URL
http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=12444292682
DOI
10.1016/j.bmcl.2004.11.010
ISSN
0960-894X
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CHM_Journal Papers
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