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Park, Cheol-Min
Synthetic & Medicinal Chemistry Lab
Research Interests
  • Organic synthesis, medicinal chemistry, chemical biology

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N-Aryl-benzimidazolones as novel small molecule HSP90 inhibitors

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Title
N-Aryl-benzimidazolones as novel small molecule HSP90 inhibitors
Author
Bruncko, MilanTahir, Stephen K.Song, XiaohongChen, JunDing, HongHuth, Jeffrey R.Jin, ShaJudge, Russell A.Madar, David J.Park, Chang H.Park, Cheol-MinPetros, Andrew M.Tse, ChristinRosenberg, Saul H.Elmore, Steven W.
Issue Date
2010-12
Publisher
PERGAMON-ELSEVIER SCIENCE LTD
Citation
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, v.20, no.24, pp.7503 - 7506
Abstract
We describe the development of a novel series of N-aryl-benzimidazolone HSP90 inhibitors (9) targeting the N-terminal ATP-ase site. SAR development was influenced by structure-based design based around X-ray structures of ligand bound HSP90 complexes. Lead compounds exhibited high binding affinities, ATP-ase inhibition and cellular client protein degradation.
URI
https://scholarworks.unist.ac.kr/handle/201301/8540
URL
http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=78449271034
DOI
10.1016/j.bmcl.2010.10.010
ISSN
0960-894X
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CHM_Journal Papers
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