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Kang, Byoung Heon
Cancer Biology Lab.
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Mitochondrial Thermogenesis Can Trigger Heat Shock Response in the Nucleus

Author(s)
Kang, Myeong-GyunKim, Hwa-RyeonLee, Hee YongKwak, ChulhwanKoh, HyewonKang, Byoung HeonRoe, Jae-SeokRhee, Hyun-Woo
Issued Date
2024-06
DOI
10.1021/acscentsci.3c01589
URI
https://scholarworks.unist.ac.kr/handle/201301/82991
Citation
ACS CENTRAL SCIENCE
Abstract
Mitochondrial thermogenesis is a process in which heat is generated by mitochondrial respiration. In living organisms, the thermogenic mechanisms that maintain body temperature have been studied extensively in fat cells with little knowledge on how mitochondrial heat may act beyond energy expenditure. Here, we highlight that the exothermic oxygen reduction reaction (Delta H-f degrees = -286 kJ/mol) is the main source of the protonophore-induced mitochondrial thermogenesis, and this heat is conducted to other cellular organelles, including the nucleus. As a result, mitochondrial heat that reached the nucleus initiated the classical heat shock response, including the formation of nuclear stress granules and the localization of heat shock factor 1 (HSF1) to chromatin. Consequently, activated HSF1 increases the level of gene expression associated with the response to thermal stress in mammalian cells. Our results illustrate heat generated within the cells as a potential source of mitochondria-nucleus communication and expand our understanding of the biological functions of mitochondria in cell physiology.
Publisher
AMER CHEMICAL SOC
ISSN
2374-7943
Keyword
DNA-BINDINGTRANSCRIPTION FACTORPHASE-TRANSITIONIN-VITROACTIVATIONPROTEINTHERMOMETERADAPTATIONMECHANISMSDRIVES

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