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강병헌
Kang, Byoung Heon

강병헌

Department of Biological Sciences(생명과학과)

Research Interests
Mitochondrial chaperones;cancer biology;cell death;metabolism;cancer stem cells;cancer therapeutics development;암생물학;미토콘드리아 샤페론;세포죽음;대사;암줄기세포;항암치료제
Lab Description
Mitochondria are critical cellular regulatory nodal points intersecting multiple regulatory pathways of cell death and metabolism. The mitochondrial chaperone TRAP1 has been reported to regulate mitochondrial cell death and metabolism. We are interested in elucidation of TRAP1 functions in cancer cell and cancer stem cells, and development of mitochondria-targeted or mitochondria-permeable TRAP1 inhibitors, SMTIN and panvotinib, respectively.
Researcher ID Research Gate ORCiD Scopus Google Scholar
Previous
Development of a Fluorescence Probe for High-Throughput Screening of Allosteric Inhibitors Targeting TRAP1 File

Yoon, Nam Gu , Choi, Danbi , Lee, Ji Hye , Kim, So-Yeon , Im, Jin Young , Yun, Jisu , Yang, Sujae , Kim, Taeeun , Kang, Soosung , Kang, Byoung Heon

Article Issue Date2024-12 View5
Mitochondrial Thermogenesis Can Trigger Heat Shock Response in the Nucleus File File

Kang, Myeong-Gyun , Kim, Hwa-Ryeon , Lee, Hee Yong , Kwak, Chulhwan , Koh, Hyewon , Kang, Byoung Heon , Roe, Jae-Seok , Rhee, Hyun-Woo

Article Issue Date2024-06 View82
Second international symposium on the chaperone code, 2023 File

Buchner, Johannes , Alasady, Milad J. , Backe, Sarah J. , Blagg, Brian S. J. , Carpenter, Richard L. , Colombo, Giorgio , Gelis, Ioannis , Gewirth, Daniel T. , Gierasch, Lila M. , Houry, Walid A. , et al

Article Issue Date2024-02 View21
Targeting the Mitochondrial Chaperone TRAP1 Alleviates Vascular Pathologies in Ischemic Retinopathy File File

Kim, So‐Yeon , Yoon, Nam Gu , Im, Jin Young , Lee, Ji Hye , Kim, Juhee , Jeon, Yujin , Choi, Young Jae , Lee, Jong‐Hwa , Uemura, Akiyoshi , Park, Dong Ho , et al

Article Issue Date2024-01 View1231
TonEBP in Myeloid Cells Promotes Obesity-Induced Insulin Resistance and Inflammation Through Adipose Tissue Remodeling File File

Lee, Hwan Hee , Jeong, Gyu Won , Ye, Byeong Jin , Yoo, Eun Jin , Son, Keoung Sun , Kim, Dong Ki , Park, Hye-Kyung , Kang, Byoung Heon , Lee-Kwon, Whaseon , Kwon, Hyug Moo , et al

Article Issue Date2022-12 View51
Structure, Function, and Inhibitors of the Mitochondrial Chaperone TRAP1 File

Kang, Soo Sung , Kang, Byoung Heon

Article Issue Date2022-12 View33
Triphenylphosphonium conjugation to a TRAP1 inhibitor, 2-amino-6--chloro-7,9-dihydro-8H-purin-8-one increases antiproliferative activity File

Yang, Sujae , Yoon, Nam Gu , Park, Min-A , Yun, Jisu , Im, Jin Young , Kang, Byoung Heon , Kang, Soosung

Article Issue Date2022-09 View59
Quaternary ammonium-based mitochondria targeting anticancer agents with high water solubility File

Kim, Sangpil , Yoon, Nam Gu , Jana, Batakrishna , Kang, Byoung Heon , Ryu, Ja-Hyoung

Article Issue Date2022-03 View43
Mitoquinone Inactivates Mitochondrial Chaperone TRAP1 by Blocking the Client Binding Site File

Yoon, Nam Gu , Lee, Hakbong , Kim, So-Yeon , Hu, Sung , Kim, Darong , Yang, Sujae , Hong, Ki Bum , Lee, Ji Hoon , Kang, Soosung , Kim, Byung-Gyu , et al

Article Issue Date2021-12 View71
Design and Synthesis of TRAP1 Selective Inhibitors: H-Bonding with Asn171 Residue in TRAP1 Increases Paralog Selectivity File

Yang, Sujae , Yoon, Nam Gu , Kim, Dongyoung , Park, Eunsun , Kim, So-Yeon , Lee, Ji Hoon , Lee, Changwook , Kang, Byoung Heon , Kang, Soosung

Article Issue Date2021-07 View42
Development of pyrazolo[3,4-d]pyrimidine-6-amine-based TRAP1 inhibitors that demonstrate in vivo anticancer activity in mouse xenograft models File

Kim, Darong , Kim, So-Yeon , Kim, Dongyoung , Yoon, Nam Gu , Yun, Jisu , Hong, Ki Bum , Lee, Changwook , Lee, Ji Hoon , Kang, Byoung Heon , Kang, Soosung

Article Issue Date2020-08 View61
Flightless-1 inhibits ER stress-induced apoptosis in colorectal cancer cells by regulating Ca2+ homeostasis File File

Choi, Sun Sil , Lee, Sang Kwon , Kim, Joong Kwan , Park, Hye-Kyung , Lee, Eujin , Jang, Jinho , Lee, Yo Han , Khim, Keon Woo , Hyun, Ji-Min , Eom, Hye-jin , et al

Article Issue Date2020-06 View71
Dual Binding to Orthosteric and Allosteric Sites Enhances the Anticancer Activity of a TRAP1-Targeting Drug File

Hu, Sung , Ferraro, Mariarosaria , Thomas, Ajesh P. , Chung, Jeong Min , Yoon, Nam Gu , Seol, Ji-Hoon , Kim, Sangpil , Kim, Han-Ul , An, Mi Young , Ok, Haewon , et al

Article Issue Date2020-03 View46
Unleashing the full potential of Hsp90 inhibitors as cancer therapeutics through simultaneous inactivation of Hsp90, Grp94, and TRAP1 File File

Park, Hye-Kyung , Yoon, Nam Gu , Lee, Ji-Eun , Hu, Sung , Yoon, Sora , Kim, So Yeon , Hong, Jun-Hee , Nam, Dougu , Chae, Young Chan , Park, Jong Bae , et al

Article Issue Date2020-01 View44
Discovery of 2-((4-resorcinolyl)-5-aryl-1,2,3-triazol-1-yl)acetates as potent Hsp90 inhibitors with selectivity over TRAP1 File

Jung, Sejin , Yoon, Nam Gu , Yang, Sujae , Kim, Darong , Lee, Won Seok , Hong, Ki Bum , Lee, Changwook , Kang, Byoung Heon , Lee, Ji Hoon , Kang, Soosung

Article Issue Date2020-01 View43
Mitochondrial Heat Shock Protein-Guided Photodynamic Therapy File

Thomas, Ajesh P. , Lee, An-Jung , Palanikumar, L , Jana, Batakrishna , Kim, Kibeom , Kim, Sangpil , Ok, Haewon , Seol, Jihoon , Kim, Dongseok , Kang, Byoung Heon , et al

Article Issue Date2019-10 View55
Interplay between TRAP1 and sirtuin-3 modulates mitochondrial respiration and oxidative stress to maintain stemness of glioma stem cells File

Park, Hye-Kyung , Hong, Jun-Hee , Oh, Young Taek , Kim, Sung Soo , Yin, Jinlong , Lee, An-Jung , Chae, Young Chan , Kim, Jong Heon , Park, Sung-Hye , Park, Chul-Kee , et al

Article Issue Date2019-04 View35
TRAP1 Inhibition Increases Glutamine Synthetase Activity in Glutamine Auxotrophic Non-small Cell Lung Cancer Cells File

Vo, Vu T. A. , Choi, Jong-Whan , Phan, Ai N. H. , Hua, Tuyen N. M. , Kim, Min-Kyu , Kang, Byoung Heon , Jung, Soon-Hee , Yong, Suk-Joong , Jeong, Yangsik

Article Issue Date2018-04 View34
Paralog Specificity Determines Subcellular Distribution, Action Mechanism, and Anticancer Activity of TRAP1 Inhibitors File

Park, Hye-Kyung , Jeong, Hanbin , Ko, Eunhwa , Lee, Geumwoo , Lee, Ji-Eun , Lee, Sang Kwang , Lee, An-Jung , Im, Jin Young , Hu, Sung , Kim, Seong Heon , et al

Article Issue Date2017-09 View44
The novel resveratrol derivative 3,5-diethoxy-3', 4'-dihydroxy-trans-stilbene induces mitochondrial ROS-mediated ER stress and cell death in human hepatoma cells in vitro File

Park, Jae-woo , Choi, Woo-gyun , Lee, Phil-jun , Chung, Su-wol , Kim, Byung-sam , Chung, Hun-taeg , Cho, Sungchan , Kim, Jong-heon , Kang, Byoung Heon , Kim, Hyoungsu , et al

Article Issue Date2017-08 View36
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