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강병헌
Kang, Byoung Heon

강병헌

생명과학과

Research Interests
Mitochondrial chaperones;cancer biology;cell death;metabolism;cancer stem cells;cancer therapeutics development;암생물학;미토콘드리아 샤페론;세포죽음;대사;암줄기세포;항암치료제
Lab Description
Mitochondria are critical cellular regulatory nodal points intersecting multiple regulatory pathways of cell death and metabolism. The mitochondrial chaperone TRAP1 has been reported to regulate mitochondrial cell death and metabolism. We are interested in elucidation of TRAP1 functions in cancer cell and cancer stem cells, and development of mitochondria-targeted or mitochondria-permeable TRAP1 inhibitors, SMTIN and panvotinib, respectively.
Researcher ID Research Gate ORCiD Scopus Google Scholar
Previous
Analysis of mitochondrial membrane potential, ROS, and calcium File

Park, Hye-Kyung , Kang, Byoung Heon

Article Issue Date2025-08 View94
Pseudohypoxic stabilization of HIF1α via cyclophilin D suppression promotes melanoma metastasis File

Park, Hye-Kyung , Hu, Sung , Kim, So Yeon , Yoon, Sora , Yoon, Nam Gu , Lee, Ji Hye , Choi, Wonyoung , Kong, Sun-Young , Kim, Jong Heon , Nam, Dougu , et al

Article Issue Date2025-07 View125
eIF2α phosphorylation-ATF4 axis-mediated transcriptional reprogramming mitigates mitochondrial impairment during ER stress File

Le, Hien Thi , Yu, Jiyoung , Ahn, Hee Sung , Kim, Mi-Jeong , Chae, In Gyeong , Cho, Hyun-Nam , Kim, Juhee , Park, Hye-Kyung , Kwon, Hyuk Nam , Chae, Han-Jung , et al

Article Issue Date2025-02 View51
Development of a Fluorescence Probe for High-Throughput Screening of Allosteric Inhibitors Targeting TRAP1 File

Yoon, Nam Gu , Choi, Danbi , Lee, Ji Hye , Kim, So-Yeon , Im, Jin Young , Yun, Jisu , Yang, Sujae , Kim, Taeeun , Kang, Soosung , Kang, Byoung Heon

Article Issue Date2024-12 View111
Mitochondrial Thermogenesis Can Trigger Heat Shock Response in the Nucleus File File

Kang, Myeong-Gyun , Kim, Hwa-Ryeon , Lee, Hee Yong , Kwak, Chulhwan , Koh, Hyewon , Kang, Byoung Heon , Roe, Jae-Seok , Rhee, Hyun-Woo

Article Issue Date2024-06 View209
Second international symposium on the chaperone code, 2023 File

Buchner, Johannes , Alasady, Milad J. , Backe, Sarah J. , Blagg, Brian S. J. , Carpenter, Richard L. , Colombo, Giorgio , Gelis, Ioannis , Gewirth, Daniel T. , Gierasch, Lila M. , Houry, Walid A. , et al

Article Issue Date2024-02 View129
Targeting the Mitochondrial Chaperone TRAP1 Alleviates Vascular Pathologies in Ischemic Retinopathy File File

Kim, So‐Yeon , Yoon, Nam Gu , Im, Jin Young , Lee, Ji Hye , Kim, Juhee , Jeon, Yujin , Choi, Young Jae , Lee, Jong‐Hwa , Uemura, Akiyoshi , Park, Dong Ho , et al

Article Issue Date2024-01 View15868
Structure, Function, and Inhibitors of the Mitochondrial Chaperone TRAP1 File

Kang, Soo Sung , Kang, Byoung Heon

Article Issue Date2022-12 View119
TonEBP in Myeloid Cells Promotes Obesity-Induced Insulin Resistance and Inflammation Through Adipose Tissue Remodeling File File

Lee, Hwan Hee , Jeong, Gyu Won , Ye, Byeong Jin , Yoo, Eun Jin , Son, Keoung Sun , Kim, Dong Ki , Park, Hye-Kyung , Kang, Byoung Heon , Lee-Kwon, Whaseon , Kwon, Hyug Moo , et al

Article Issue Date2022-12 View172
Triphenylphosphonium conjugation to a TRAP1 inhibitor, 2-amino-6--chloro-7,9-dihydro-8H-purin-8-one increases antiproliferative activity File

Yang, Sujae , Yoon, Nam Gu , Park, Min-A , Yun, Jisu , Im, Jin Young , Kang, Byoung Heon , Kang, Soosung

Article Issue Date2022-09 View167
Quaternary ammonium-based mitochondria targeting anticancer agents with high water solubility File

Kim, Sangpil , Yoon, Nam Gu , Jana, Batakrishna , Kang, Byoung Heon , Ryu, Ja-Hyoung

Article Issue Date2022-03 View154
Mitoquinone Inactivates Mitochondrial Chaperone TRAP1 by Blocking the Client Binding Site File

Yoon, Nam Gu , Lee, Hakbong , Kim, So-Yeon , Hu, Sung , Kim, Darong , Yang, Sujae , Hong, Ki Bum , Lee, Ji Hoon , Kang, Soosung , Kim, Byung-Gyu , et al

Article Issue Date2021-12 View184
Design and Synthesis of TRAP1 Selective Inhibitors: H-Bonding with Asn171 Residue in TRAP1 Increases Paralog Selectivity File

Yang, Sujae , Yoon, Nam Gu , Kim, Dongyoung , Park, Eunsun , Kim, So-Yeon , Lee, Ji Hoon , Lee, Changwook , Kang, Byoung Heon , Kang, Soosung

Article Issue Date2021-07 View138
Development of pyrazolo[3,4-d]pyrimidine-6-amine-based TRAP1 inhibitors that demonstrate in vivo anticancer activity in mouse xenograft models File

Kim, Darong , Kim, So-Yeon , Kim, Dongyoung , Yoon, Nam Gu , Yun, Jisu , Hong, Ki Bum , Lee, Changwook , Lee, Ji Hoon , Kang, Byoung Heon , Kang, Soosung

Article Issue Date2020-08 View163
Flightless-1 inhibits ER stress-induced apoptosis in colorectal cancer cells by regulating Ca2+ homeostasis File File

Choi, Sun Sil , Lee, Sang Kwon , Kim, Joong Kwan , Park, Hye-Kyung , Lee, Eujin , Jang, Jinho , Lee, Yo Han , Khim, Keon Woo , Hyun, Ji-Min , Eom, Hye-jin , et al

Article Issue Date2020-06 View207
Dual Binding to Orthosteric and Allosteric Sites Enhances the Anticancer Activity of a TRAP1-Targeting Drug File

Hu, Sung , Ferraro, Mariarosaria , Thomas, Ajesh P. , Chung, Jeong Min , Yoon, Nam Gu , Seol, Ji-Hoon , Kim, Sangpil , Kim, Han-Ul , An, Mi Young , Ok, Haewon , et al

Article Issue Date2020-03 View173
Discovery of 2-((4-resorcinolyl)-5-aryl-1,2,3-triazol-1-yl)acetates as potent Hsp90 inhibitors with selectivity over TRAP1 File

Jung, Sejin , Yoon, Nam Gu , Yang, Sujae , Kim, Darong , Lee, Won Seok , Hong, Ki Bum , Lee, Changwook , Kang, Byoung Heon , Lee, Ji Hoon , Kang, Soosung

Article Issue Date2020-01 View167
Unleashing the full potential of Hsp90 inhibitors as cancer therapeutics through simultaneous inactivation of Hsp90, Grp94, and TRAP1 File File

Park, Hye-Kyung , Yoon, Nam Gu , Lee, Ji-Eun , Hu, Sung , Yoon, Sora , Kim, So Yeon , Hong, Jun-Hee , Nam, Dougu , Chae, Young Chan , Park, Jong Bae , et al

Article Issue Date2020-01 View169
Mitochondrial Heat Shock Protein-Guided Photodynamic Therapy File

Thomas, Ajesh P. , Lee, An-Jung , Palanikumar, L , Jana, Batakrishna , Kim, Kibeom , Kim, Sangpil , Ok, Haewon , Seol, Jihoon , Kim, Dongseok , Kang, Byoung Heon , et al

Article Issue Date2019-10 View190
Interplay between TRAP1 and sirtuin-3 modulates mitochondrial respiration and oxidative stress to maintain stemness of glioma stem cells File

Park, Hye-Kyung , Hong, Jun-Hee , Oh, Young Taek , Kim, Sung Soo , Yin, Jinlong , Lee, An-Jung , Chae, Young Chan , Kim, Jong Heon , Park, Sung-Hye , Park, Chul-Kee , et al

Article Issue Date2019-04 View128
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