File Download

  • Find it @ UNIST can give you direct access to the published full text of this article. (UNISTARs only)
Related Researcher

강병헌

Kang, Byoung Heon
Cancer Biology Lab.
Read More

Views & Downloads

Detailed Information

Cited time in webofscience Cited time in scopus
Metadata Downloads

Full metadata record

DC Field Value Language
dc.citation.title ACS CENTRAL SCIENCE -
dc.contributor.author Kang, Myeong-Gyun -
dc.contributor.author Kim, Hwa-Ryeon -
dc.contributor.author Lee, Hee Yong -
dc.contributor.author Kwak, Chulhwan -
dc.contributor.author Koh, Hyewon -
dc.contributor.author Kang, Byoung Heon -
dc.contributor.author Roe, Jae-Seok -
dc.contributor.author Rhee, Hyun-Woo -
dc.date.accessioned 2024-06-14T14:35:10Z -
dc.date.available 2024-06-14T14:35:10Z -
dc.date.created 2024-06-12 -
dc.date.issued 2024-06 -
dc.description.abstract Mitochondrial thermogenesis is a process in which heat is generated by mitochondrial respiration. In living organisms, the thermogenic mechanisms that maintain body temperature have been studied extensively in fat cells with little knowledge on how mitochondrial heat may act beyond energy expenditure. Here, we highlight that the exothermic oxygen reduction reaction (Delta H-f degrees = -286 kJ/mol) is the main source of the protonophore-induced mitochondrial thermogenesis, and this heat is conducted to other cellular organelles, including the nucleus. As a result, mitochondrial heat that reached the nucleus initiated the classical heat shock response, including the formation of nuclear stress granules and the localization of heat shock factor 1 (HSF1) to chromatin. Consequently, activated HSF1 increases the level of gene expression associated with the response to thermal stress in mammalian cells. Our results illustrate heat generated within the cells as a potential source of mitochondria-nucleus communication and expand our understanding of the biological functions of mitochondria in cell physiology. -
dc.identifier.bibliographicCitation ACS CENTRAL SCIENCE -
dc.identifier.doi 10.1021/acscentsci.3c01589 -
dc.identifier.issn 2374-7943 -
dc.identifier.scopusid 2-s2.0-85195260912 -
dc.identifier.uri https://scholarworks.unist.ac.kr/handle/201301/82991 -
dc.identifier.wosid 001238289700001 -
dc.language 영어 -
dc.publisher AMER CHEMICAL SOC -
dc.title Mitochondrial Thermogenesis Can Trigger Heat Shock Response in the Nucleus -
dc.type Article -
dc.description.isOpenAccess TRUE -
dc.relation.journalWebOfScienceCategory Chemistry, Multidisciplinary -
dc.relation.journalResearchArea Chemistry -
dc.type.docType Article; Early Access -
dc.description.journalRegisteredClass scie -
dc.description.journalRegisteredClass scopus -
dc.subject.keywordPlus DNA-BINDING -
dc.subject.keywordPlus TRANSCRIPTION FACTOR -
dc.subject.keywordPlus PHASE-TRANSITION -
dc.subject.keywordPlus IN-VITRO -
dc.subject.keywordPlus ACTIVATION -
dc.subject.keywordPlus PROTEIN -
dc.subject.keywordPlus THERMOMETER -
dc.subject.keywordPlus ADAPTATION -
dc.subject.keywordPlus MECHANISMS -
dc.subject.keywordPlus DRIVES -

qrcode

Items in Repository are protected by copyright, with all rights reserved, unless otherwise indicated.