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Myung, Kyungjae
Center for Genomic Integrity
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GABAergic-like dopamine synapses in health and Parkinsonism

Kim, Hyun-JinHwang, ByungjaeReva, MariaLee, JieunLee, Byeong EunLee, YoungeunCho, Eun JeongLee, Seung EunMyung, KyungjaeBaik, Ja-HyunPark, Jung-HoonKim, Jae-Ick
Issued Date
The 25th Annual Meeting of the Korean Society for Brain and Neural Sciences
Dopamine synapses play a crucial role for volitional movement and reward-
related behaviors, while dysfunction of dopamine synapses causes
various psychiatric and neurological disorders. Despite this significance,
true biological nature of dopamine synapses remains poorly understood in
the brain. Here we show that dopamine transmission is strongly correlated
with GABA co-transmission across the brain and dopamine synapses are
structured and function like GABAergic synapses with marked regional heterogeneity.
In addition, GABAergic-like dopamine synapses are uniquely
clustered on the dendrites and GABA transmission at dopamine synapses
has distinct physiological properties. Interestingly, knockdown of neuroligin-
2, a key postsynaptic protein at GABAergic synapses, unexpectedly
does not weaken GABA co-transmission but instead facilitates it at dopamine
synapses in the striatal neurons. More importantly, the attenuation
of GABA co-transmission precedes deficits in dopaminergic transmission
in an animal model of Parkinsonism. Our findings reveal unknown spatial
and functional nature of GABAergic-like dopamine synapses in health and
Korean Society for Brain and Neural Sciences


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