File Download

There are no files associated with this item.

  • Find it @ UNIST can give you direct access to the published full text of this article. (UNISTARs only)
Related Researcher


Myung, Kyungjae
Center for Genomic Integrity
Read More

Views & Downloads

Detailed Information

Cited time in webofscience Cited time in scopus
Metadata Downloads

GABAergic-like dopamine synapses in health and Parkinsonism

Kim, Hyun-JinHwang, ByungjaeReva, MariaLee, JieunLee, Byeong EunLee, YoungeunCho, Eun JeongLee, Seung EunMyung, KyungjaeBaik, Ja-HyunPark, Jung-HoonKim, Jae-Ick
Issued Date
KSBMB International Conference 2022
Dopamine synapses play a crucial role for volitional movement and reward-related behaviors, while
dysfunction of dopamine synapses causes various psychiatric and neurological disorders. Despite this significance,
true biological nature of dopamine synapses remains poorly understood in the brain. Here we show
that dopamine transmission is strongly correlated with GABA co-transmission across the brain and
dopamine synapses are structured and function like GABAergic synapses with marked regional
heterogeneity. In addition, GABAergic-like dopamine synapses are uniquely clustered on the
dendrites and GABA transmission at dopamine synapses has distinct physiological properties.
Interestingly, knockdown of neuroligin-2, a key postsynaptic protein at GABAergic synapses,
unexpectedly does not weaken GABA co-transmission but instead facilitates it at dopamine synapses
in the striatal neurons. More importantly, the attenuation of GABA co-transmission precedes
deficits in dopaminergic transmission in an animal model of Parkinsonism. Our findings reveal
unknown spatial and functional nature of GABAergic-like dopamine synapses in health and disease.
Korean Society for Biochemistry and Molecular Biology


Items in Repository are protected by copyright, with all rights reserved, unless otherwise indicated.