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Suh, Pann-Ghill
BioSignal Network Lab (BSN)
Research Interests
  • Signal transduction, cancer, metabolism, phospholipase C

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Phospholipase C-epsilon augments epidermal growth factor-dependent cell growth by inhibiting epidermal growth factor receptor down-regulation

Cited 9 times inthomson ciCited 13 times inthomson ci
Title
Phospholipase C-epsilon augments epidermal growth factor-dependent cell growth by inhibiting epidermal growth factor receptor down-regulation
Author
Yun, SangukHong, Won-PyoChoi, Jang HyunYi, Kye SookChae, Suhn-KeeRyu, Sung HoSuh, Pann-Ghill
Issue Date
2008-01
Publisher
AMER SOC BIOCHEMISTRY MOLECULAR BIOLOGY INC
Citation
JOURNAL OF BIOLOGICAL CHEMISTRY, v.283, no.1, pp.341 - 349
Abstract
The down-regulation of the epidermal growth factor (EGF) receptor is critical for the termination of EGF-dependent signaling, and the dysregulation of this process can lead to oncogenesis. In the present study, we suggest a novel mechanism for the regulation of EGF receptor down-regulation by phospholipase C-ε. The overexpression of PLC-ε led to an increase in receptor recycling and decreased the down-regulation of the EGF receptor in COS-7 cells. Adaptor protein complex 2 (AP2) was identified as a novel binding protein that associates with the PLC-ε RA2 domain independently of Ras. The interaction of PLC-ε with AP2 was responsible for the suppression of EGF receptor down-regulation, since a perturbation in this interaction abolished this effect. Enhanced EGF receptor stability by PLC-ε led to the potentiation of EGF-dependent growth in COS-7 cells. Finally, the knockdown of PLC-ε in mouse embryo fibroblast cells elicited a severe defect in EGF-dependent growth. Our results indicated that PLC-ε could promote EGF-dependent cell growth by suppressing receptor down-regulation.
URI
https://scholarworks.unist.ac.kr/handle/201301/7243
URL
http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=38049100855
DOI
10.1074/jbc.M704180200
ISSN
0021-9258
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BIO_Journal Papers
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