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DC Field | Value | Language |
---|---|---|
dc.citation.endPage | 349 | - |
dc.citation.number | 1 | - |
dc.citation.startPage | 341 | - |
dc.citation.title | JOURNAL OF BIOLOGICAL CHEMISTRY | - |
dc.citation.volume | 283 | - |
dc.contributor.author | Yun, Sanguk | - |
dc.contributor.author | Hong, Won-Pyo | - |
dc.contributor.author | Choi, Jang Hyun | - |
dc.contributor.author | Yi, Kye Sook | - |
dc.contributor.author | Chae, Suhn-Kee | - |
dc.contributor.author | Ryu, Sung Ho | - |
dc.contributor.author | Suh, Pann-Ghill | - |
dc.date.accessioned | 2023-12-22T09:06:27Z | - |
dc.date.available | 2023-12-22T09:06:27Z | - |
dc.date.created | 2014-10-14 | - |
dc.date.issued | 2008-01 | - |
dc.description.abstract | The down-regulation of the epidermal growth factor (EGF) receptor is critical for the termination of EGF-dependent signaling, and the dysregulation of this process can lead to oncogenesis. In the present study, we suggest a novel mechanism for the regulation of EGF receptor down-regulation by phospholipase C-ε. The overexpression of PLC-ε led to an increase in receptor recycling and decreased the down-regulation of the EGF receptor in COS-7 cells. Adaptor protein complex 2 (AP2) was identified as a novel binding protein that associates with the PLC-ε RA2 domain independently of Ras. The interaction of PLC-ε with AP2 was responsible for the suppression of EGF receptor down-regulation, since a perturbation in this interaction abolished this effect. Enhanced EGF receptor stability by PLC-ε led to the potentiation of EGF-dependent growth in COS-7 cells. Finally, the knockdown of PLC-ε in mouse embryo fibroblast cells elicited a severe defect in EGF-dependent growth. Our results indicated that PLC-ε could promote EGF-dependent cell growth by suppressing receptor down-regulation. | - |
dc.identifier.bibliographicCitation | JOURNAL OF BIOLOGICAL CHEMISTRY, v.283, no.1, pp.341 - 349 | - |
dc.identifier.doi | 10.1074/jbc.M704180200 | - |
dc.identifier.issn | 0021-9258 | - |
dc.identifier.scopusid | 2-s2.0-38049100855 | - |
dc.identifier.uri | https://scholarworks.unist.ac.kr/handle/201301/7243 | - |
dc.identifier.url | http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=38049100855 | - |
dc.identifier.wosid | 000251940300038 | - |
dc.language | 영어 | - |
dc.publisher | AMER SOC BIOCHEMISTRY MOLECULAR BIOLOGY INC | - |
dc.title | Phospholipase C-epsilon augments epidermal growth factor-dependent cell growth by inhibiting epidermal growth factor receptor down-regulation | - |
dc.type | Article | - |
dc.description.isOpenAccess | FALSE | - |
dc.description.journalRegisteredClass | scopus | - |
dc.subject.keywordPlus | CLATHRIN | - |
dc.subject.keywordPlus | RAS | - |
dc.subject.keywordPlus | AP-2 | - |
dc.subject.keywordPlus | TRAFFICKING | - |
dc.subject.keywordPlus | ENDOCYTOSIS | - |
dc.subject.keywordPlus | EXPRESSION | - |
dc.subject.keywordPlus | EFFECTOR | - |
dc.subject.keywordPlus | ADAPTERS | - |
dc.subject.keywordPlus | SUBUNIT | - |
dc.subject.keywordPlus | DOMAINS | - |
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