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최장현
Choi, Jang Hyun

최장현

Department of Biological Sciences(생명과학과)

  • Lab of Diabetes and Metabolism Lab.
  • Website
Research Interests
Diabetes;Metabolic Disorders;Gene Regulation;PPARg;당뇨;대사질환;유전자조절
Lab Description
Obesity is a major risk factor for metabolic diseases such as type 2 diabetes, dyslipidemia, cardiovascular disease and cancers. The number of patients with metabolic diseases rapidly increasing and is reaching the levels of infectious diseases.Our lab is interested in understanding the molecular pathways that link adipose tissue biology to this staggering array of pathologies such as diabetes and metabolic diseases. These studies can be the scientific basis for developing novel anti-diabetic agents.
Researcher ID Research Gate ORCiD Scopus Google Scholar
Previous
Alkylation of nucleobases by 2-chloro-N,N-diethylethanamine hydrochloride (CDEAH) sensitizes PARP1-deficient tumors File File

Wie, Minwoo , Khim, Keon Woo , Groehler Iv, Arnold S , Heo, Soomin , Woo, Junhyeok , Son, Kook , Lee, Eun A , Ra, Jae Sun , Hong, Sung You , Scharer, Orlando D. , et al

Article Issue Date2023-09 View81
Alteration of replication protein A binding mode on single-stranded DNA by NSMF potentiates RPA phosphorylation by ATR kinase File File

Kang, Yujin , Han, Ye Gi , Khim, Keon Woo , Choi, Woo Gyun , Ju, Min Kyung , Park, Kibeom , Shin, Kyeong Jin , Chae, Young Chan , Choi, Jang Hyun , Kim, Hongtae , et al

Article Issue Date2023-08 View36
Precision targeting tumor cells using cancer-specific InDel mutations with CRISPR-Cas9 File

Kwon, Taejoon , Ra, Jae Sun , Lee, Soyoung , Baek, In-Joon , Khim, Keon Woo , Lee, Eun A , Song, Eun Kyung , Otarbayev, Daniyar , Jung, Woojae , Park, Yong Hwan , et al

Article Issue Date2022-03 View44
Hepatic MIR20B promotes nonalcoholic fatty liver disease by suppressing PPARA File

Lee, Yo Han , Jang, Hyun-Jun , Kim, Sounkou , Choi, Sun Sil , Khim, Keon Woo , Eom, Hye-Jin , Hyun, Jimin , Shin, Kyeong Jin , Chae, Young Chan , Kim, Hongtae , et al

Article Issue Date2021-12 View33
Vernicia fordii (Hemsl.) Airy Shaw extract stimulates insulin secretion in pancreatic beta-cells and improves insulin sensitivity in diabetic mice File

Hyun, Jimin , Park, Mi Hyeon , Lee, Yo Han , Lee, Youngeun , Jeong, Su Ji , Choi, Sun Sil , Khim, Keon Woo , Eom, Hye Jin , Hur, Jin-Hoe , Park, Chan Young , et al

Article Issue Date2021-10 View47
Thrap3 promotes R-loop resolution via interaction with methylated DDX5 File

Kang, Hyun Je , Eom, Hye-jin , Kim, Hongtae , Myung, Kyungjae , Kwon, Hyug Moo , Choi, Jang Hyun

Article Issue Date2021-10 View56
NSMF promotes the replication stress-induced DNA damage response for genome maintenance File

Ju, Min Kyung , Shin, Kyeong Jin , Lee, Joo Rak , Khim, Keon Woo , Lee, Eun A , Ra, Jae Sun , Kim, Byung-Gyu , Jo, Han-seul , Yoon, Jong Hyuk , Kim, Tae Moon , et al

Article Issue Date2021-06 View40
Phospholipase Cγ의 생리적 기능과 질병과 연관된 돌연변이 File

장현준 , 최장현 , 장종수

Article Issue Date2020-09 View25
Flightless-1 inhibits ER stress-induced apoptosis in colorectal cancer cells by regulating Ca2+ homeostasis File File

Choi, Sun Sil , Lee, Sang Kwon , Kim, Joong Kwan , Park, Hye-Kyung , Lee, Eujin , Jang, Jinho , Lee, Yo Han , Khim, Keon Woo , Hyun, Ji-Min , Eom, Hye-jin , et al

Article Issue Date2020-06 View48
Broussonetia papyrifera Root Bark Extract Exhibits Anti-inflammatory Effects on Adipose Tissue and Improves Insulin Sensitivity Potentially Via AMPK Activation File File

Lee, Jae Min , Choi, Sun Sil , Park, Mi Hyeon , Jang, Hyunduk , Lee, Yo Han , Khim, Keon Woo , Oh, Sei Ryang , Park, Jiyoung , Ryu, Hyung Won , Choi, Jang Hyun

Article Issue Date2020-03 View30
PPM1A Controls Diabetic Gene Programming through Directly Dephosphorylating PPARγ at Ser273 File File

Khim, Keon Woo , Choi, Sun Sil , Jang, Hyun-Jun , Lee, Yo Han , Lee, Eujin , Hyun, Ji-Min , Eom, Hye-Jin , Yoon, Sora , Choi, Jeong-Won , Park, Tae-Eun , et al

Article Issue Date2020-02 View33
Glucosylceramide synthase regulates adipo‐osteogenic differentiation through synergistic activation of PPARγ with GlcCer File

Jang, Hyun-Jun , Lim, Seyoung , Kim, Jung-Min , Yoon, Sora , Lee, Chae Young , Hwang, Hyeon-Jeong , Shim, Jeong Woo , Shin, Kyeong Jin , Kim, Hye Yun , Park, Kwang Il , et al

Article Issue Date2020-01 View34
Phospholipase C-β1 potentiates glucose-stimulated insulin secretion File

Hwang, Hyeon-Jeong , Yang, Yong Ryoul , Kim, Hye Yun , Choi, Yoonji , Park, Kyoung-Su , Lee, Ho , Ma, Ji Su , Yamamoto, Masahiro , Kim, Jaeyoon , Chae, Young Chan , et al

Article Issue Date2019-10 View28
Rational design and synthesis of reversible covalent PPARγ antagonistic ligands inhibiting Ser273 phosphorylation File

Kim, Hyunsoo , Jo, Ala , Choi, Sun-sil , Nam, Hyunsung , Byun. Wan Gi , Bae, Hwan , Choi, Jang Hyun , Park, Seung Bum

Article Issue Date2019-09 View36
Inhibition of oncogenic Src induces FABP4-mediated lipolysis via PPARγ activation exerting cancer growth suppression File

Hua, Tuyen N.M. , Kim, Min-Kyu , Vo, Vu T.A. , Choi, Jong-Whan , Choi, Jang Hyun , Kim, Hyun-Won , Cha, Seung-Kuy , Park, Kyu-Sang , Jeong, Yangsik

Article Issue Date2019-03 View29
COL6A3-derived endotrophin links reciprocal interactions among hepatic cells in the pathology of chronic liver disease File

Lee, Changu , Kim, Min , Lee, Jun Ho , Oh, Jiyoung , Shin, Hyun-Hee , Lee, Sang Min , Scherer, Philipp , Kwon, H. Moo , Choi, Jang Hyun , Park, Jiyoung

Article Issue Date2019-01 View49
The E3 ubiquitin ligase TRIM25 regulates adipocyte differentiation via proteasomemediated degradation of PPAR gamma File File

Lee, Jae Min , Choi, Sun Sil , Lee, Yo Han , Khim, Keon Woo , Yoon, Sora , Kim, Byung-Gyu , Nam, Dougu , Suh, Pann-Ghill , Myung, Kyungjae , Choi, Jang Hyun

Article Issue Date2018-10 View25
RASAL3 preferentially stimulates GTP hydrolysis of the Rho family small GTPase Rac2 File

Shin, Yoonjae , Kim, Yong Woo , Kim, Hyemin , Shin, Nakyoung , Kim, Tae Sung , Kwon, Taeg Kyu , Choi, Jang Hyun , Chang, Jong-Soo

Article Issue Date2018-09 View58
Flightless-I Controls Fat Storage in Drosophila File File

Park, Jung-Eun , Lee, Eun Ji , Kim, Jung Kwan , Song, Youngsup , Choi, Jang Hyun , Kang, Min-Ji

Article Issue Date2018-06 View28
Zafirlukast promotes insulin secretion by increasing calcium influx through L-type calcium channels File

Hwang, Hyeon-Jeong , Park, Kyoung-Su , Choi, Jang Hyun , Cocco, Lucio , Jang, Hyun-Jun , Suh, Pann-Ghill

Article Issue Date2018-05 View27
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