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Park, Chan Young
Calcium Dynamics Lab
Research Interests
  • Calcium Signaling, Calcium Channels, Immune, neuroscience, Drug Development, Virus and host cell interaction.

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Arabidopsis ubiquitin-specific protease 6 (AtUBP6) interacts with calmodulin

Cited 8 times inthomson ciCited 9 times inthomson ci
Title
Arabidopsis ubiquitin-specific protease 6 (AtUBP6) interacts with calmodulin
Author
Moon, BCChoi, MSKang, YHKim, MCCheong, MSPark, Chan YoungYoo, JHKoo, SCLee, SMLim, COCho, Moo JeChung, WS
Issue Date
2005-07
Publisher
ELSEVIER SCIENCE BV
Citation
FEBS LETTERS, v.579, no.18, pp.3885 - 3890
Abstract
Calmodulin (CaM), a key Ca2+ sensor in eukaryotes, regulates diverse cellular processes by interacting with many proteins. To identify Ca2+/CaM-mediated signaling components, we screened an Arabidopsis expression library with horseradish peroxidase-conjugated Arabidopsis calmodulin2 (AtCaM2) and isolated a homolog of the UBP6 deubiquitinating enzyme family (AtUBP6) containing a Ca2+-dependent CaM-binding domain (CaMBD). The CaM-binding activity of the AtUBP6 CaMBD was confirmed by CaM mobility shift assay, phosphodiesterase competition assay and site-directed mutagenesis. Furthermore, expression of AtUBP6 restored canavanine resistance to the Delta ubp6 yeast mutant. This is the first demonstration that Ca2+ signaling via CaM is involved in ubiquitin-mediated protein degradation and/or stabilization in plants.
URI
https://scholarworks.unist.ac.kr/handle/201301/7188
URL
http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=21844436532
DOI
10.1016/j.febslet.2005.05.080
ISSN
0014-5793
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BIO_Journal Papers
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