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Park, Jiyoung
Molecular Metabolism Laboratory (MML)
Research Interests
  • Obesity, diabetes, adipose tissue, cancer, cancer-associated adipocyte, dermal adipocyte, metabolic memory

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Increase in glucose-6-phosphate dehydrogenase in adipocytes stimulates oxidative stress and inflammatory signals

Cited 66 times inthomson ciCited 65 times inthomson ci
Title
Increase in glucose-6-phosphate dehydrogenase in adipocytes stimulates oxidative stress and inflammatory signals
Author
Park, JiyoungChoe, Sung SikChoi, A. HyunKim, Kang HoYoon, Myeong JinSuganami, TakayoshiOgawa, YoshihiroKim, Jae Bum
Keywords
INDUCED INSULIN-RESISTANCE; NF-KAPPA-B; IKK-BETA; TARGETED DISRUPTION; ADIPOSE-TISSUE; PROTEIN-KINASE; NITRIC-OXIDE; OBESITY; ACTIVATION; PATHWAYS
Issue Date
2006-11
Publisher
AMER DIABETES ASSOC
Citation
DIABETES, v.55, no.11, pp.2939 - 2949
Abstract
In adipocytes, oxidative stress and chronic inflammation are closely associated with metabolic disorders, including insulin resistance, obesity, cardiovascular disease, and type 2 diabetes. However, the molecular mechanisms underlying these metabolic disorders have not been thoroughly elucidated. In this report, we demonstrate that overexpression of glucose-6-phosphate dehydrogenase (G6PD) in adipocytes stimulates oxidative stress and in-flammatory responses, thus affecting the neighboring macrophages. Adipogenic G6PD overexpression promotes the expression of pro-oxidative enzymes, including inducible nitric oxide synthase and NADPH oxidase, and the activation of nuclear factor-κB (NF-κB) signaling, which eventually leads to the dysregulation of adipocytokines and inflammatory signals. Furthermore, secretory factors from G6PD-overexpressing adipocytes stimulate macrophages to express more proinflammatory cytokines and to be recruited to the adipocytes; this would cause chronic inflammatory conditions in the adipose tissue of obesity. These effects of G6PD overexpression in adipocytes were abolished by pretreatment with NF-κB inhibitors or antioxidant drugs. Thus, we propose that a high level of G6PD in adipocytes may mediate the onset of metabolic disorders in obesity by increasing the oxidative stress and inflammatory signals.
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DOI
10.2337/db05-1570
ISSN
0012-1797
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BME_Journal Papers
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