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DC Field | Value | Language |
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dc.citation.endPage | 2949 | - |
dc.citation.number | 11 | - |
dc.citation.startPage | 2939 | - |
dc.citation.title | DIABETES | - |
dc.citation.volume | 55 | - |
dc.contributor.author | Park, Jiyoung | - |
dc.contributor.author | Choe, Sung Sik | - |
dc.contributor.author | Choi, A. Hyun | - |
dc.contributor.author | Kim, Kang Ho | - |
dc.contributor.author | Yoon, Myeong Jin | - |
dc.contributor.author | Suganami, Takayoshi | - |
dc.contributor.author | Ogawa, Yoshihiro | - |
dc.contributor.author | Kim, Jae Bum | - |
dc.date.accessioned | 2023-12-22T09:40:39Z | - |
dc.date.available | 2023-12-22T09:40:39Z | - |
dc.date.created | 2014-10-13 | - |
dc.date.issued | 2006-11 | - |
dc.description.abstract | In adipocytes, oxidative stress and chronic inflammation are closely associated with metabolic disorders, including insulin resistance, obesity, cardiovascular disease, and type 2 diabetes. However, the molecular mechanisms underlying these metabolic disorders have not been thoroughly elucidated. In this report, we demonstrate that overexpression of glucose-6-phosphate dehydrogenase (G6PD) in adipocytes stimulates oxidative stress and in-flammatory responses, thus affecting the neighboring macrophages. Adipogenic G6PD overexpression promotes the expression of pro-oxidative enzymes, including inducible nitric oxide synthase and NADPH oxidase, and the activation of nuclear factor-κB (NF-κB) signaling, which eventually leads to the dysregulation of adipocytokines and inflammatory signals. Furthermore, secretory factors from G6PD-overexpressing adipocytes stimulate macrophages to express more proinflammatory cytokines and to be recruited to the adipocytes; this would cause chronic inflammatory conditions in the adipose tissue of obesity. These effects of G6PD overexpression in adipocytes were abolished by pretreatment with NF-κB inhibitors or antioxidant drugs. Thus, we propose that a high level of G6PD in adipocytes may mediate the onset of metabolic disorders in obesity by increasing the oxidative stress and inflammatory signals. | - |
dc.identifier.bibliographicCitation | DIABETES, v.55, no.11, pp.2939 - 2949 | - |
dc.identifier.doi | 10.2337/db05-1570 | - |
dc.identifier.issn | 0012-1797 | - |
dc.identifier.scopusid | 2-s2.0-33845596741 | - |
dc.identifier.uri | https://scholarworks.unist.ac.kr/handle/201301/7183 | - |
dc.identifier.url | http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=33845596741 | - |
dc.identifier.wosid | 000241966500002 | - |
dc.language | 영어 | - |
dc.publisher | AMER DIABETES ASSOC | - |
dc.title | Increase in glucose-6-phosphate dehydrogenase in adipocytes stimulates oxidative stress and inflammatory signals | - |
dc.type | Article | - |
dc.description.journalRegisteredClass | scopus | - |
dc.subject.keywordPlus | INDUCED INSULIN-RESISTANCE | - |
dc.subject.keywordPlus | NF-KAPPA-B | - |
dc.subject.keywordPlus | IKK-BETA | - |
dc.subject.keywordPlus | TARGETED DISRUPTION | - |
dc.subject.keywordPlus | ADIPOSE-TISSUE | - |
dc.subject.keywordPlus | PROTEIN-KINASE | - |
dc.subject.keywordPlus | NITRIC-OXIDE | - |
dc.subject.keywordPlus | OBESITY | - |
dc.subject.keywordPlus | ACTIVATION | - |
dc.subject.keywordPlus | PATHWAYS | - |
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