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Park, Jiyoung
Molecular Metabolism Laboratory (MML)
Research Interests
  • Obesity, diabetes, adipose tissue, cancer, cancer-associated adipocyte, dermal adipocyte, metabolic memory

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Catechin gallates are NADP(+)-competitive inhibitors of glucose-6-phosphate dehydrogenase and other enzymes that employ NADP(+) as a coenzyme

Cited 16 times inthomson ciCited 18 times inthomson ci
Title
Catechin gallates are NADP(+)-competitive inhibitors of glucose-6-phosphate dehydrogenase and other enzymes that employ NADP(+) as a coenzyme
Author
Shin, Eui SeokPark, JiyoungShin, Jae-MinCho, DoohoCho, Si YoungShin, Dong WookHam, MiraKim, Jae BumLee, Tae Ryong
Issue Date
2008-04
Publisher
PERGAMON-ELSEVIER SCIENCE LTD
Citation
BIOORGANIC & MEDICINAL CHEMISTRY, v.16, no.7, pp.3580 - 3586
Abstract
Recent studies have shown that glucose-6-phosphate dehydrogenase (G6PD) is an effectual therapeutic target for metabolic disorders, including obesity and diabetes. In this study, we used in silico and conventional screening approaches to identify putative inhibitors of G6PD and found that gallated catechins (EGCG, GCG, ECG, CG), but not ungallated catechins (ECG, GC, EC, C), were NADP+-competitive inhibitors of G6PD and other enzymes that employ NADP+ as a coenzyme, such as IDH and 6PGD.
URI
https://scholarworks.unist.ac.kr/handle/201301/7178
URL
http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=41649106850
DOI
10.1016/j.bmc.2008.02.030
ISSN
0968-0896
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BIO_Journal Papers
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