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DC Field | Value | Language |
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dc.citation.endPage | 3586 | - |
dc.citation.number | 7 | - |
dc.citation.startPage | 3580 | - |
dc.citation.title | BIOORGANIC & MEDICINAL CHEMISTRY | - |
dc.citation.volume | 16 | - |
dc.contributor.author | Shin, Eui Seok | - |
dc.contributor.author | Park, Jiyoung | - |
dc.contributor.author | Shin, Jae-Min | - |
dc.contributor.author | Cho, Dooho | - |
dc.contributor.author | Cho, Si Young | - |
dc.contributor.author | Shin, Dong Wook | - |
dc.contributor.author | Ham, Mira | - |
dc.contributor.author | Kim, Jae Bum | - |
dc.contributor.author | Lee, Tae Ryong | - |
dc.date.accessioned | 2023-12-22T08:42:05Z | - |
dc.date.available | 2023-12-22T08:42:05Z | - |
dc.date.created | 2014-10-13 | - |
dc.date.issued | 2008-04 | - |
dc.description.abstract | Recent studies have shown that glucose-6-phosphate dehydrogenase (G6PD) is an effectual therapeutic target for metabolic disorders, including obesity and diabetes. In this study, we used in silico and conventional screening approaches to identify putative inhibitors of G6PD and found that gallated catechins (EGCG, GCG, ECG, CG), but not ungallated catechins (ECG, GC, EC, C), were NADP+-competitive inhibitors of G6PD and other enzymes that employ NADP+ as a coenzyme, such as IDH and 6PGD. | - |
dc.identifier.bibliographicCitation | BIOORGANIC & MEDICINAL CHEMISTRY, v.16, no.7, pp.3580 - 3586 | - |
dc.identifier.doi | 10.1016/j.bmc.2008.02.030 | - |
dc.identifier.issn | 0968-0896 | - |
dc.identifier.scopusid | 2-s2.0-41649106850 | - |
dc.identifier.uri | https://scholarworks.unist.ac.kr/handle/201301/7178 | - |
dc.identifier.url | http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=41649106850 | - |
dc.identifier.wosid | 000255245900010 | - |
dc.language | 영어 | - |
dc.publisher | PERGAMON-ELSEVIER SCIENCE LTD | - |
dc.title | Catechin gallates are NADP(+)-competitive inhibitors of glucose-6-phosphate dehydrogenase and other enzymes that employ NADP(+) as a coenzyme | - |
dc.type | Article | - |
dc.description.journalRegisteredClass | scopus | - |
dc.subject.keywordAuthor | catechin gallate | - |
dc.subject.keywordAuthor | glucose-6-phosphate dehydrogenase | - |
dc.subject.keywordAuthor | isocitrate dehydrogenase | - |
dc.subject.keywordAuthor | 6-phosphogluconate dehydrogenase | - |
dc.subject.keywordAuthor | NADP | - |
dc.subject.keywordPlus | GREEN TEA CATECHINS | - |
dc.subject.keywordPlus | FATTY-ACID SYNTHASE | - |
dc.subject.keywordPlus | DEHYDROEPIANDROSTERONE-SULFATE | - |
dc.subject.keywordPlus | EPIGALLOCATECHIN GALLATE | - |
dc.subject.keywordPlus | OXIDATIVE STRESS | - |
dc.subject.keywordPlus | OBESITY | - |
dc.subject.keywordPlus | CANCER | - |
dc.subject.keywordPlus | CARCINOGENESIS | - |
dc.subject.keywordPlus | DEHYDROGENASE | - |
dc.subject.keywordPlus | POLYPHENOLS | - |
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