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Park, Jiyoung
Molecular Metabolism Laboratory (MML)
Research Interests
  • Obesity, diabetes, adipose tissue, cancer, cancer-associated adipocyte, dermal adipocyte, metabolic memory

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Leptin and cancer: from cancer stem cells to metastasis

Cited 7 times inthomson ciCited 8 times inthomson ci
Title
Leptin and cancer: from cancer stem cells to metastasis
Author
Park, JiyoungScherer, Philipp E.
Issue Date
2011-08
Publisher
BIOSCIENTIFICA LTD
Citation
ENDOCRINE-RELATED CANCER, v.18, no.4, pp.C25 - C29
Abstract
There is growing evidence that obesity is a risk factor of cancer incidence and mortality. Hence, the identification of the mechanistic links between obesity and cancer progression is emerging as a topic of widespread interest. Recently, several groups have addressed the functional roles of leptin, an adipocyte-derived adipokine, for mammary tumor progression. In this issue of Endocrine-Related Cancer, Zheng et al. study the role of leptin on tumor growth in a xenograft model of MMTV-Wnt1-derived cancer cells. They study growth of these cancer cells in the context of obese animals, such as ob/ob mice (lacking leptin) and db/db mice (lacking functional leptin receptors (LEPR)) and find that leptin triggers LEPR-positive cancer stem cell differentiation, thereby promoting tumor cell survival. These findings highlight the therapeutic potential for leptin and leptin signaling in the context of mammary tumor growth.
URI
https://scholarworks.unist.ac.kr/handle/201301/7163
URL
http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=80052178858
DOI
10.1530/ERC-11-0163
ISSN
1351-0088
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BIO_Journal Papers
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