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DC Field | Value | Language |
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dc.citation.endPage | C29 | - |
dc.citation.number | 4 | - |
dc.citation.startPage | C25 | - |
dc.citation.title | ENDOCRINE-RELATED CANCER | - |
dc.citation.volume | 18 | - |
dc.contributor.author | Park, Jiyoung | - |
dc.contributor.author | Scherer, Philipp E. | - |
dc.date.accessioned | 2023-12-22T06:07:00Z | - |
dc.date.available | 2023-12-22T06:07:00Z | - |
dc.date.created | 2014-10-13 | - |
dc.date.issued | 2011-08 | - |
dc.description.abstract | There is growing evidence that obesity is a risk factor of cancer incidence and mortality. Hence, the identification of the mechanistic links between obesity and cancer progression is emerging as a topic of widespread interest. Recently, several groups have addressed the functional roles of leptin, an adipocyte-derived adipokine, for mammary tumor progression. In this issue of Endocrine-Related Cancer, Zheng et al. study the role of leptin on tumor growth in a xenograft model of MMTV-Wnt1-derived cancer cells. They study growth of these cancer cells in the context of obese animals, such as ob/ob mice (lacking leptin) and db/db mice (lacking functional leptin receptors (LEPR)) and find that leptin triggers LEPR-positive cancer stem cell differentiation, thereby promoting tumor cell survival. These findings highlight the therapeutic potential for leptin and leptin signaling in the context of mammary tumor growth. | - |
dc.identifier.bibliographicCitation | ENDOCRINE-RELATED CANCER, v.18, no.4, pp.C25 - C29 | - |
dc.identifier.doi | 10.1530/ERC-11-0163 | - |
dc.identifier.issn | 1351-0088 | - |
dc.identifier.scopusid | 2-s2.0-80052178858 | - |
dc.identifier.uri | https://scholarworks.unist.ac.kr/handle/201301/7163 | - |
dc.identifier.url | http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=80052178858 | - |
dc.identifier.wosid | 000294996100002 | - |
dc.language | 영어 | - |
dc.publisher | BIOSCIENTIFICA LTD | - |
dc.title | Leptin and cancer: from cancer stem cells to metastasis | - |
dc.type | Article | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.subject.keywordPlus | MAMMARY-TUMOR GROWTH | - |
dc.subject.keywordPlus | BREAST-CANCER | - |
dc.subject.keywordPlus | FEMALE MICE | - |
dc.subject.keywordPlus | DB/DB MICE | - |
dc.subject.keywordPlus | RECEPTOR | - |
dc.subject.keywordPlus | OBESITY | - |
dc.subject.keywordPlus | EXPRESSION | - |
dc.subject.keywordPlus | WEIGHT | - |
dc.subject.keywordPlus | DEFICIENCY | - |
dc.subject.keywordPlus | OVERWEIGHT | - |
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