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Park, Jiyoung
Molecular Metabolism Laboratory (MML)
Research Interests
  • Obesity, diabetes, adipose tissue, cancer, cancer-associated adipocyte, dermal adipocyte, metabolic memory

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Neuregulin 1-HER axis as a key mediator of hyperglycemic memory effects in breast cancer

Cited 3 times inthomson ciCited 3 times inthomson ci
Title
Neuregulin 1-HER axis as a key mediator of hyperglycemic memory effects in breast cancer
Author
Park, JiyoungSarode, Venetia R.Euhus, DavidKittler, RalfScherer, Philipp E.
Issue Date
2012-12
Publisher
NATL ACAD SCIENCES
Citation
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, v.109, no.51, pp.21058 - 21063
Abstract
Poor outcomes in diabetic patients are observed across a range of human tumors, suggesting that cancer cells develop unique characteristics under diabetic conditions. Cancer cells exposed to hyperglycemic insults acquire permanent aggressive traits of tumor growth, even after a return to euglycemic conditions. Comparative genome-wide mapping of hyperglycemia-specific open chromatin regions and concomitant mRNA expression profiling revealed that the neuregulin-1 gene, encoding an established endogenous ligand for the HER3 receptor, is activated through a putative distal enhancer. Our findings highlight the targeted inhibition of NRG1-HER3 pathways as a potential target for the treatment breast cancer patients with associated diabetes.
URI
https://scholarworks.unist.ac.kr/handle/201301/7142
URL
http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=84871361983
DOI
10.1073/pnas.1214400109
ISSN
0027-8424
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BIO_Journal Papers
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