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Park, Jiyoung
Molecular Metabolism Laboratory (MML)
Research Interests
  • Obesity, diabetes, adipose tissue, cancer, cancer-associated adipocyte, dermal adipocyte, metabolic memory

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Neuregulin 1-HER axis as a key mediator of hyperglycemic memory effects in breast cancer

DC Field Value Language
dc.contributor.author Park, Jiyoung ko
dc.contributor.author Sarode, Venetia R. ko
dc.contributor.author Euhus, David ko
dc.contributor.author Kittler, Ralf ko
dc.contributor.author Scherer, Philipp E. ko
dc.date.available 2014-10-16T01:40:26Z -
dc.date.created 2014-10-13 ko
dc.date.issued 2012-12 ko
dc.identifier.citation PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, v.109, no.51, pp.21058 - 21063 ko
dc.identifier.issn 0027-8424 ko
dc.identifier.uri https://scholarworks.unist.ac.kr/handle/201301/7142 -
dc.description.abstract Poor outcomes in diabetic patients are observed across a range of human tumors, suggesting that cancer cells develop unique characteristics under diabetic conditions. Cancer cells exposed to hyperglycemic insults acquire permanent aggressive traits of tumor growth, even after a return to euglycemic conditions. Comparative genome-wide mapping of hyperglycemia-specific open chromatin regions and concomitant mRNA expression profiling revealed that the neuregulin-1 gene, encoding an established endogenous ligand for the HER3 receptor, is activated through a putative distal enhancer. Our findings highlight the targeted inhibition of NRG1-HER3 pathways as a potential target for the treatment breast cancer patients with associated diabetes. ko
dc.description.statementofresponsibility close -
dc.language 영어 ko
dc.publisher NATL ACAD SCIENCES ko
dc.title Neuregulin 1-HER axis as a key mediator of hyperglycemic memory effects in breast cancer ko
dc.type ARTICLE ko
dc.identifier.scopusid 2-s2.0-84871361983 ko
dc.identifier.wosid 000313123700064 ko
dc.type.rims ART ko
dc.description.wostc 3 *
dc.description.scopustc 3 *
dc.date.tcdate 2015-05-06 *
dc.date.scptcdate 2014-10-13 *
dc.identifier.doi 10.1073/pnas.1214400109 ko
dc.identifier.url http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=84871361983 ko
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