Two-Component Genetic Switch as a Synthetic Module with Tunable Stability
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- Two-Component Genetic Switch as a Synthetic Module with Tunable Stability
- Ghim, Cheol-Min; Almaas, E.
- Issue Date
- AMER PHYSICAL SOC
- PHYSICAL REVIEW LETTERS, v.103, no.2, pp.1 - 4
- Despite stochastic fluctuations, some genetic switches are able to retain their expression states through multiple cell divisions, providing epigenetic memory. We propose a novel rationale for tuning the functional stability of a simple synthetic gene switch through protein dimerization. Introducing an approximation scheme to access long-time stochastic dynamics of multiple-component gene circuits, we find that the spontaneous switching rate may exhibit greater than 8orders of magnitude variation. The manipulation of the circuit's biochemical properties offers a practical strategy for designing robust epigenetic memory with synthetic circuits.
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