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Ghim, Cheol-Min
Physical Biology & Biological Physics
Research Interests
  • Control of complex networks, Stochastic fluctuations in a cell, Biochemical information processing, Human microbiome, Ecological inference, Nonequilibrium active system

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Two-Component Genetic Switch as a Synthetic Module with Tunable Stability

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Title
Two-Component Genetic Switch as a Synthetic Module with Tunable Stability
Author
Ghim, Cheol-MinAlmaas, E.
Issue Date
2009-07
Publisher
AMER PHYSICAL SOC
Citation
PHYSICAL REVIEW LETTERS, v.103, no.2, pp.1 - 4
Abstract
Despite stochastic fluctuations, some genetic switches are able to retain their expression states through multiple cell divisions, providing epigenetic memory. We propose a novel rationale for tuning the functional stability of a simple synthetic gene switch through protein dimerization. Introducing an approximation scheme to access long-time stochastic dynamics of multiple-component gene circuits, we find that the spontaneous switching rate may exhibit greater than 8orders of magnitude variation. The manipulation of the circuit's biochemical properties offers a practical strategy for designing robust epigenetic memory with synthetic circuits.
URI
https://scholarworks.unist.ac.kr/handle/201301/7088
URL
http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=68649088120
DOI
10.1103/PhysRevLett.103.028101
ISSN
0031-9007
Appears in Collections:
PHY_Journal Papers
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