dc.citation.endPage |
4 |
- |
dc.citation.number |
2 |
- |
dc.citation.startPage |
1 |
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dc.citation.title |
PHYSICAL REVIEW LETTERS |
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dc.citation.volume |
103 |
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dc.contributor.author |
Ghim, Cheol-Min |
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dc.contributor.author |
Almaas, E. |
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dc.date.accessioned |
2023-12-22T07:44:02Z |
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dc.date.available |
2023-12-22T07:44:02Z |
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dc.date.created |
2014-10-10 |
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dc.date.issued |
2009-07 |
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dc.description.abstract |
Despite stochastic fluctuations, some genetic switches are able to retain their expression states through multiple cell divisions, providing epigenetic memory. We propose a novel rationale for tuning the functional stability of a simple synthetic gene switch through protein dimerization. Introducing an approximation scheme to access long-time stochastic dynamics of multiple-component gene circuits, we find that the spontaneous switching rate may exhibit greater than 8orders of magnitude variation. The manipulation of the circuit's biochemical properties offers a practical strategy for designing robust epigenetic memory with synthetic circuits. |
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dc.identifier.bibliographicCitation |
PHYSICAL REVIEW LETTERS, v.103, no.2, pp.1 - 4 |
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dc.identifier.doi |
10.1103/PhysRevLett.103.028101 |
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dc.identifier.issn |
0031-9007 |
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dc.identifier.scopusid |
2-s2.0-68649088120 |
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dc.identifier.uri |
https://scholarworks.unist.ac.kr/handle/201301/7088 |
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dc.identifier.url |
http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=68649088120 |
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dc.identifier.wosid |
000267887800062 |
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dc.language |
영어 |
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dc.publisher |
AMER PHYSICAL SOC |
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dc.title |
Two-Component Genetic Switch as a Synthetic Module with Tunable Stability |
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dc.type |
Article |
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dc.description.journalRegisteredClass |
scopus |
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