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Kang, Byoung Heon
Cancer Biology Lab
Research Interests
  • Mitochondrial chaperones, cancer biology, cell death, metabolism, cancer stem cells, cancer therapeutics development

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Compartmentalized cancer drug discovery targeting mitochondrial Hsp90 chaperones

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dc.contributor.author Kang, Byoung Heon ko
dc.contributor.author Altieri, D. C. ko
dc.date.available 2014-10-13T01:26:44Z -
dc.date.created 2014-10-10 ko
dc.date.issued 2009-10 ko
dc.identifier.citation ONCOGENE, v.28, no.42, pp.3681 - 3688 ko
dc.identifier.issn 0950-9232 ko
dc.identifier.uri https://scholarworks.unist.ac.kr/handle/201301/7086 -
dc.description.abstract There is a plethora of attractive drug targets in cancer, but their therapeutic exploitation proved more difficult than expected, and only rarely truly successful. One possibility not often considered in drug discovery is that cancer signaling pathways are not randomly arranged in cells, but orchestrated in specialized subcellular compartments. The identification of heat shock protein-90 (Hsp90) chaperones in mitochondria of tumors, but not most normal tissues, provides an example of a compartmentalized network of cell survival, opening fresh prospects for novel, subcellularly targeted cancer drug discovery. ko
dc.description.statementofresponsibility close -
dc.language 영어 ko
dc.publisher NATURE PUBLISHING GROUP ko
dc.title Compartmentalized cancer drug discovery targeting mitochondrial Hsp90 chaperones ko
dc.type ARTICLE ko
dc.identifier.scopusid 2-s2.0-70350568650 ko
dc.identifier.wosid 000271023200001 ko
dc.type.rims ART ko
dc.description.wostc 25 *
dc.description.scopustc 23 *
dc.date.tcdate 2015-05-06 *
dc.date.scptcdate 2014-10-10 *
dc.identifier.doi 10.1038/onc.2009.227 ko
dc.identifier.url http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=70350568650 ko
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