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Kang, Byoung Heon
Cancer Biology Lab
Research Interests
  • Mitochondrial chaperones, cancer biology, cell death, metabolism, cancer stem cells, cancer therapeutics development


Compartmentalized cancer drug discovery targeting mitochondrial Hsp90 chaperones

DC Field Value Language Kang, Byoung Heon ko Altieri, D. C. ko 2014-10-13T01:26:44Z - 2014-10-10 ko 2009-10 ko
dc.identifier.citation ONCOGENE, v.28, no.42, pp.3681 - 3688 ko
dc.identifier.issn 0950-9232 ko
dc.identifier.uri -
dc.description.abstract There is a plethora of attractive drug targets in cancer, but their therapeutic exploitation proved more difficult than expected, and only rarely truly successful. One possibility not often considered in drug discovery is that cancer signaling pathways are not randomly arranged in cells, but orchestrated in specialized subcellular compartments. The identification of heat shock protein-90 (Hsp90) chaperones in mitochondria of tumors, but not most normal tissues, provides an example of a compartmentalized network of cell survival, opening fresh prospects for novel, subcellularly targeted cancer drug discovery. ko
dc.description.statementofresponsibility close -
dc.language 영어 ko
dc.title Compartmentalized cancer drug discovery targeting mitochondrial Hsp90 chaperones ko
dc.type ARTICLE ko
dc.identifier.scopusid 2-s2.0-70350568650 ko
dc.identifier.wosid 000271023200001 ko
dc.type.rims ART ko
dc.description.wostc 25 *
dc.description.scopustc 23 * 2015-05-06 * 2014-10-10 *
dc.identifier.doi 10.1038/onc.2009.227 ko
dc.identifier.url ko
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