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Lee, Dong Woog
Interfacial Physics and Chemistry Laboratory
Research Interests
  • Bio/Bio-inspired adhesion and lubrication, friction of skin and sensory perception, wetting behavior of various surfaces, surface physics and chemistry of low-dimensional materials

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Antigen-Antibody Interaction-Derived Bioadhesion of Bacterial Cellulose Nanofibers to Promote Topical Wound Healing

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Title
Antigen-Antibody Interaction-Derived Bioadhesion of Bacterial Cellulose Nanofibers to Promote Topical Wound Healing
Author
Kim, SeulgiKo, JinaChoi, Jae HyukKang, Jeong YiLim, ChanoongShin, MikyungLee, Dong WoogKim, Jin Woong
Issue Date
2022-05
Publisher
John Wiley & Sons Ltd.
Citation
ADVANCED FUNCTIONAL MATERIALS, v.32, no.20, pp.2110557
Abstract
A practically helpful bioadhesion system can be developed for biomedical treatments by taking advantage of the antigen–antibody interaction in which an antibody binds to a protein with specific lock and key binding affinity. This study presents a new type of skin tissue adhesive system in which an involucrin antibody (SY5)-conjugated bacterial cellulose nanofiber (BCNF) is bound to involucrin (IVL) in corneocytes of the stratum corneum. For this, the SY5 is covalently incorporated on the surface of carboxylate of 2,2,6,6-tetramethylpiperidine-1-oxyl radical (TEMPO)-oxidized BCNFs via the 1-ethyl-3-(3-dimethylaminopropyl) carbodiimide (EDC)/N-hydroxysuccinimide (NHS) coupling reaction. It is shown that the SY5-conjugated BCNF (BCNFSY5) exhibits the antigen–antibody interaction with the IVL, eventually leading to effective adhesion to the skin surface. Moreover, it is demonstrated that the BCNF-based skin adhesion promotes wound healing by basically providing a tissue environment where cell proliferation can occur actively. These results emphasize that the BCNFSY5 system could pave the way for developing a new type of tissue adhesive for skin tissue regeneration.
URI
https://scholarworks.unist.ac.kr/handle/201301/55322
URL
https://onlinelibrary.wiley.com/doi/full/10.1002/adfm.202110557
DOI
10.1002/adfm.202110557
ISSN
1616-301X
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