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DC Field | Value | Language |
---|---|---|
dc.citation.number | 20 | - |
dc.citation.startPage | 2110557 | - |
dc.citation.title | ADVANCED FUNCTIONAL MATERIALS | - |
dc.citation.volume | 32 | - |
dc.contributor.author | Kim, Seulgi | - |
dc.contributor.author | Ko, Jina | - |
dc.contributor.author | Choi, Jae Hyuk | - |
dc.contributor.author | Kang, Jeong Yi | - |
dc.contributor.author | Lim, Chanoong | - |
dc.contributor.author | Shin, Mikyung | - |
dc.contributor.author | Lee, Dong Woog | - |
dc.contributor.author | Kim, Jin Woong | - |
dc.date.accessioned | 2023-12-21T14:13:16Z | - |
dc.date.available | 2023-12-21T14:13:16Z | - |
dc.date.created | 2021-12-21 | - |
dc.date.issued | 2022-05 | - |
dc.description.abstract | A practically helpful bioadhesion system can be developed for biomedical treatments by taking advantage of the antigen–antibody interaction in which an antibody binds to a protein with specific lock and key binding affinity. This study presents a new type of skin tissue adhesive system in which an involucrin antibody (SY5)-conjugated bacterial cellulose nanofiber (BCNF) is bound to involucrin (IVL) in corneocytes of the stratum corneum. For this, the SY5 is covalently incorporated on the surface of carboxylate of 2,2,6,6-tetramethylpiperidine-1-oxyl radical (TEMPO)-oxidized BCNFs via the 1-ethyl-3-(3-dimethylaminopropyl) carbodiimide (EDC)/N-hydroxysuccinimide (NHS) coupling reaction. It is shown that the SY5-conjugated BCNF (BCNFSY5) exhibits the antigen–antibody interaction with the IVL, eventually leading to effective adhesion to the skin surface. Moreover, it is demonstrated that the BCNF-based skin adhesion promotes wound healing by basically providing a tissue environment where cell proliferation can occur actively. These results emphasize that the BCNFSY5 system could pave the way for developing a new type of tissue adhesive for skin tissue regeneration. | - |
dc.identifier.bibliographicCitation | ADVANCED FUNCTIONAL MATERIALS, v.32, no.20, pp.2110557 | - |
dc.identifier.doi | 10.1002/adfm.202110557 | - |
dc.identifier.issn | 1616-301X | - |
dc.identifier.scopusid | 2-s2.0-85122734277 | - |
dc.identifier.uri | https://scholarworks.unist.ac.kr/handle/201301/55322 | - |
dc.identifier.url | https://onlinelibrary.wiley.com/doi/full/10.1002/adfm.202110557 | - |
dc.identifier.wosid | 000742539200001 | - |
dc.language | 영어 | - |
dc.publisher | John Wiley & Sons Ltd. | - |
dc.title | Antigen-Antibody Interaction-Derived Bioadhesion of Bacterial Cellulose Nanofibers to Promote Topical Wound Healing | - |
dc.type | Article | - |
dc.description.isOpenAccess | FALSE | - |
dc.relation.journalWebOfScienceCategory | ChemistryScience & Technology - Other TopicsMaterials SciencePhysics | - |
dc.relation.journalResearchArea | ChemistryScience & Technology - Other TopicsMaterials SciencePhysics | - |
dc.type.docType | Article | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
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