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Kwon, Hyug Moo
Immunometabolism and Cancer Lab
Research Interests
  • TonEBP, Obesity, Cancer, Chronic inflammatory diseases, Brain disorder, Kidney disorder, Genomic instability

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THE HUMAN OSMOREGULATORY NA+/MYO-INOSITOL COTRANSPORTER GENE (SLC5A3) - MOLECULAR-CLONING AND LOCALIZATION TO CHROMOSOME-21

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Title
THE HUMAN OSMOREGULATORY NA+/MYO-INOSITOL COTRANSPORTER GENE (SLC5A3) - MOLECULAR-CLONING AND LOCALIZATION TO CHROMOSOME-21
Author
BERRY, GTMALLEE, JJKwon, H. MooRIM, JSMULLA, WRMUENKE, MSPINNER, NB
Issue Date
1995-01
Publisher
ACADEMIC PRESS INC ELSEVIER SCIENCE
Citation
GENOMICS, v.25, no.2, pp.507 - 513
Abstract
A human Na+/myo-inositol cotransporter (SLC5A3) gene was cloned; sequencing revealed a single intron-free open reading frame of 2157 nucleotides. Containing 718 amino acid residues, the predicted protein is highly homologous to the product of the canine osmoregulatory SLC5A3 gene. The SLC5A3 protein is number 3 of the solute carrier family 5 and was previously designated SMIT. Using fluorescence in situ hybridization, the human SLC5A3 gene was localized to band q22 on chromosome 21. Many tissues including brain demonstrate gene expression. The inability of a trisomic 21 cell to downregulate expression of three copies of this osmoregulatory gene could result in increased flux of both myo-inositol and Na+ across the plasma membrane. The potential consequences include perturbations in the cell membrane potential and tissue osmolyte levels. The SLC5A3 gene may play a role in the pathogenesis of Down syndrome.
URI
https://scholarworks.unist.ac.kr/handle/201301/4915
URL
http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=0028949226
DOI
10.1016/0888-7543(95)80052-N
ISSN
0888-7543
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BIO_Journal Papers
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