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권혁무
Kwon, Hyug Moo

권혁무

Department of Biological Sciences(생명과학과)

  • Immunometabolism and Cancer Lab.
  • Website
Research Interests
Chronic inflammatory diseases;Brain disorder;Kidney disorder;Obesity;Cancer;TonEBP;Genomic instability;Metabolic syndrome;만성염증질환;뇌질환;신장질환;비만;암;유전체 불안정성;대사 증후군
Lab Description
Emerging data revealed the critical role of the TonEBP (NFAT5), initially identified as a central DNA binding transcription factors, in inflammatory diseases including rheumatoid arthritis, atherosclerosis, and chronic kidney disease. We suggested that TonEBP is a critical factor in diet-induced obesity, cancer, brain disorders and autoimmune disease. Our research group investigates cellular and molecular pathway of TonEBP action in a variety of inflammatory diseases and develops anti-inflammatory agents targeting TonEBP.
Researcher ID Research Gate ORCiD Scopus Google Scholar
Previous
One-hit kill: On the inactivation of RNA viruses by ultraviolet (UV)-C-induced genomic damage File

Park, Hyun , Shin, Go Woon , Lee, Sang Min , Jeong, Gyu Won , Kim, Hui Young , Kim, Hajin , Choi, Hyun Woo , Lee-Kwon, Whaseon , Kwon, Hyug Moo

Article Issue Date2024-08 View15
TonEBP inhibits ciliogenesis by controlling aurora kinase A and regulating centriolar satellite integrity File File

Chinbold, Batchingis , Kwon, Hyug Moo , Park, Raekil

Article Issue Date2024-07 View18
Serum amyloid A expression in liver promotes synovial macrophage activation and chronic arthritis via NFAT5 File File

Li, Meiling , Kim, Yu-Mi , Koh, Jung Hee , Park, Jihyun , Kwon, Hyug Moo , Park, Jong-Hwan , Jin, Jingchun , Park, Youngjae , Kim, Donghyun , Kim, Wan-Uk

Article Issue Date2024-03 View25
TFEB activation triggers pexophagy for functional adaptation during oxidative stress under calcium deficient-conditions File File

Manandhar, Laxman , Dutta, Raghbendra Kumar , Devkota, Pradeep , Chhetri, Arun , Wei, Xiaofan , Park, Channy , Kwon, Hyug Moo , Park, Raekil

Article Issue Date2024-02 View23
Extracellular sodium regulates fibroblast growth factor 23 (FGF23) formation File File

Radvanyi, Zsuzsa , Yoo, Eun Jin , Kandasamy, Palanivel , Salas-Bastos, Adrian , Monnerat, Sophie , Refardt, Julie , Christ-Crain, Mirjam , Hayashi, Himeka , Kondo, Yasuhiko , Jantsch, Jonathan , et al

Article Issue Date2024-01 View20
Macrophage transcription factor TonEBP promotes systemic lupus erythematosus and kidney injury via damage-induced signaling pathways File File

Yoo, Eun Jin , Oh, Kook-Hwan , Piao, Honglin , Kang, Hyun Je , Jeong, Gyu Won , Park, Hyun , Lee, Chang Jun , Ryu, Hyunjin , Yang, Seung Hee , Kim, Myung-Gyu , et al

Article Issue Date2023-07 View46
Catalase-deficient mice induce aging faster through lysosomal dysfunction File

Dutta, Raghbendra Kumar , Lee, Joon No , Maharjan, Yunash , Park, Channy , Choe, Seong-Kyu , Ho, Ye-Shih , Kwon, Hyug Moo , Park, Raekil

Article Issue Date2022-12 View25
TonEBP in Myeloid Cells Promotes Obesity-Induced Insulin Resistance and Inflammation Through Adipose Tissue Remodeling File File

Lee, Hwan Hee , Jeong, Gyu Won , Ye, Byeong Jin , Yoo, Eun Jin , Son, Keoung Sun , Kim, Dong Ki , Park, Hye-Kyung , Kang, Byoung Heon , Lee-Kwon, Whaseon , Kwon, Hyug Moo , et al

Article Issue Date2022-12 View38
Intracellular cholesterol transport inhibition Impairs autophagy flux by decreasing autophagosome-lysosome fusion File File

Maharjan, Yunash , Dutta, Raghbendra Kumar , Son, Jinbae , Wei, Xiaofan , Park, Channy , Kwon, Hyug Moo , Park, Raekil

Article Issue Date2022-11 View31
Loss of adipose TET proteins enhances β-adrenergic responses and protects against obesity by epigenetic regulation of β3-AR expression File File

Byun, Seongjun , Lee, Chan Hyeong , Jeong, Hyumgmin , Kim, Hyejin , Kwon, Hyug Moo , Park, Sung Ho , Myung, Kyungjae , An, Jungeun , Ko, Myunggon

Article Issue Date2022-06 View32
Thrap3 promotes R-loop resolution via interaction with methylated DDX5 File

Kang, Hyun Je , Eom, Hye-jin , Kim, Hongtae , Myung, Kyungjae , Kwon, Hyug Moo , Choi, Jang Hyun

Article Issue Date2021-10 View55
PARP1-mediated PARylation of TonEBP prevents R-loop-associated DNA damage File

Ye, Byeong Jin , Kang, Hyun Je , Lee-Kwon, Whaseon , Kwon, Hyug Moo , Choi, Soo Youn

Article Issue Date2021-08 View32
TonEBP recognizes R-loops and initiates m6A RNA methylation for R-loop resolution File File

Kang, Hyun Je , Cheon, Na Young , Park, Hyun , Jeong, Gyu Won , Ye, Byeong Jin , Yoo, Eun Jin , Lee, Jun Ho , Hur, Jin-Hoe , Lee, Eun-A , Kim, Hongtae , et al

Article Issue Date2021-01 View36
Microglial TonEBP mediates LPS-induced inflammation and memory loss as transcriptional cofactor for NF-kappa B and AP-1 File File

Jeong, Gyu Won , Lee, Hwan Hee , Lee-Kwon, Whaseon , Kwon, Hyug Moo

Article Issue Date2020-12 View26
TonEBP Promotes beta-Cell Survival under ER Stress by Enhancing Autophagy File File

Kang, Hyun Je , Yoo, Eun Jin , Lee, Hwan Hee , An, Seung Min , Park, Hyun , Lee-Kwon, Whaseon , Choi, Soo Youn , Kwon, Hyug Moo

Article Issue Date2020-09 View45
Tonicity-responsive enhancer-binding protein promotes stemness of liver cancer and cisplatin resistance File File

Lee, Jun Ho , Suh, Jae Hee , Kang, Hyun Je , Choi, Soo Youn , Jung, Seok Won , Lee-Kwon, Whaseon , Park, Soo-Ah , Kim, Hajin , Ye, Byeong Jin , Yoo, Eun Jin , et al

Article Issue Date2020-08 View42
The evolving role of TonEBP as an immunometabolic stress protein File

Choi, Soo Youn , Lee-Kwon, Whaseon , Kwon, Hyug Moo

Article Issue Date2020-06 View28
TonEBP in dendritic cells mediates pro-inflammatory maturation and Th1/Th17 responses File File

Ye, Byeong Jin , Lee, Hwan Hee , Yoo, Eun Jin , Lee, Chae Young , Lee, Jun Ho , Kang, Hyun Je , Jeong, Gyu Won , Park, Hyun , Lee-Kwon, Whaseon , Choi, Soo Youn , et al

Article Issue Date2020-06 View22
Tonicity-responsive enhancer binding protein (TonEBP) regulates TNF-alpha-induced hypothalamic inflammation File

Kim, Han Rae , Kim, Dong Hee , Kim, Kwang Kon , Jeong, Bora , Kang, Dasol , Lee, Tae Hwan , Park, Jeong Woo , Kwon, Hyug Moo , Lee, Byung Ju

Article Issue Date2019-10 View21
Transcriptional Regulator TonEBP Mediates Oxidative Damages in Ischemic Kidney Injury File File

Yoo, Eun Jin , Lim, Sun Woo , Kang, Hyun Je , Park, Hyun , Yoon, Sora , Nam, Dougu , Sanada, Satoru , Kwon, Mi Jin , Lee-Kwon, Whaseon , Choi, Soo Youn , et al

Article Issue Date2019-10 View44
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