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Kwon, Hyug Moo
Immunometabolism and Cancer Lab
Research Interests
  • TonEBP, Obesity, Cancer, Chronic inflammatory diseases, Brain disorder, Kidney disorder, Genomic instability

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THE HUMAN OSMOREGULATORY NA+/MYO-INOSITOL COTRANSPORTER GENE (SLC5A3) - MOLECULAR-CLONING AND LOCALIZATION TO CHROMOSOME-21

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dc.contributor.author BERRY, GT ko
dc.contributor.author MALLEE, JJ ko
dc.contributor.author Kwon, H. Moo ko
dc.contributor.author RIM, JS ko
dc.contributor.author MULLA, WR ko
dc.contributor.author MUENKE, M ko
dc.contributor.author SPINNER, NB ko
dc.date.available 2014-06-09T02:38:10Z -
dc.date.created 2014-06-03 ko
dc.date.issued 1995-01 ko
dc.identifier.citation GENOMICS, v.25, no.2, pp.507 - 513 ko
dc.identifier.issn 0888-7543 ko
dc.identifier.uri https://scholarworks.unist.ac.kr/handle/201301/4915 -
dc.description.abstract A human Na+/myo-inositol cotransporter (SLC5A3) gene was cloned; sequencing revealed a single intron-free open reading frame of 2157 nucleotides. Containing 718 amino acid residues, the predicted protein is highly homologous to the product of the canine osmoregulatory SLC5A3 gene. The SLC5A3 protein is number 3 of the solute carrier family 5 and was previously designated SMIT. Using fluorescence in situ hybridization, the human SLC5A3 gene was localized to band q22 on chromosome 21. Many tissues including brain demonstrate gene expression. The inability of a trisomic 21 cell to downregulate expression of three copies of this osmoregulatory gene could result in increased flux of both myo-inositol and Na+ across the plasma membrane. The potential consequences include perturbations in the cell membrane potential and tissue osmolyte levels. The SLC5A3 gene may play a role in the pathogenesis of Down syndrome. ko
dc.description.statementofresponsibility close -
dc.language 영어 ko
dc.publisher ACADEMIC PRESS INC ELSEVIER SCIENCE ko
dc.title THE HUMAN OSMOREGULATORY NA+/MYO-INOSITOL COTRANSPORTER GENE (SLC5A3) - MOLECULAR-CLONING AND LOCALIZATION TO CHROMOSOME-21 ko
dc.type ARTICLE ko
dc.identifier.scopusid 2-s2.0-0028949226 ko
dc.identifier.wosid A1995QH77900021 ko
dc.type.rims ART ko
dc.description.wostc 76 *
dc.date.tcdate 2015-05-06 *
dc.identifier.doi 10.1016/0888-7543(95)80052-N ko
dc.identifier.url http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=0028949226 ko
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