File Download

There are no files associated with this item.

  • Find it @ UNIST can give you direct access to the published full text of this article. (UNISTARs only)
Related Researcher


Kim, Jae-Ick
Neural Circuit and Neurodegenerative Disease Lab.
Read More

Views & Downloads

Detailed Information

Cited time in webofscience Cited time in scopus
Metadata Downloads

Full metadata record

DC Field Value Language
dc.citation.startPage 107171 -
dc.citation.volume 169 - Lee, Jaehyun - Lee, Hye-Ryeon - Kim, Jae-Ick - Baek, Jinhee - Jang, Eun-Hae - Lee, Jihye - Kim, Myeongwon - Lee, Ro Un - Kim, Somi - Park, Pojeong - Kaang, Bong-Kiun - 2023-12-21T17:51:04Z - 2023-12-21T17:51:04Z - 2020-02-10 - 2020-03 -
dc.description.abstract Memory is stored in our brains over a temporally graded transition. With time, recently formed memories are transformed into remote memories for permanent storage; multiple brain regions, such as the hippocampus and neocortex, participate in this process. In this study, we aimed to understand the molecular mechanism of systems consolidation of memory and to investigate the brain regions that contribute to this regulation. We first carried out a contextual fear memory test using a transgenic mouse line, which expressed exogenously-derived Aplysia octopamine receptors in the forebrain region, such that, in response to octopamine treatment, cyclic adenosine monophosphate (cAMP) levels could be transiently elevated. From this experiment, we revealed that transient elevation of cAMP levels in the forebrain during systems consolidation led to an enhancement in remote fear memory and increased miniature excitatory synaptic currents in layer II/III of the anterior cingulate cortex (ACC). Furthermore, using an adeno-associated-virus-driven DREADD system, we investigated the specific regions in the forebrain that contribute to the regulation of memory transfer into long-term associations. Our results implied that transient elevation of cAMP levels was induced chemogenetically in the ACC, but not in the hippocampus, and showed a significant enhancement of remote memory. This finding suggests that neuronal activation during systems consolidation through the elevation of cAMP levels in the ACC contributes to remote memory enhancement. -
dc.identifier.bibliographicCitation NEUROBIOLOGY OF LEARNING AND MEMORY, v.169, pp.107171 -
dc.identifier.doi 10.1016/j.nlm.2020.107171 -
dc.identifier.issn 1074-7427 -
dc.identifier.scopusid 2-s2.0-85078303385 -
dc.identifier.uri -
dc.identifier.url -
dc.identifier.wosid 000520948500018 -
dc.language 영어 -
dc.publisher Academic Press -
dc.title Transient cAMP elevation during systems consolidation enhances remote contextual fear memory -
dc.type Article -
dc.description.isOpenAccess FALSE -
dc.type.docType Article -
dc.description.journalRegisteredClass scie -
dc.description.journalRegisteredClass ssci -
dc.description.journalRegisteredClass scopus -
dc.subject.keywordAuthor Remote fear memory -
dc.subject.keywordAuthor Anterior cingulate cortex -
dc.subject.keywordAuthor Hippocampus -
dc.subject.keywordAuthor cAMP/PKA pathway -
dc.subject.keywordAuthor Memory transfer -
dc.subject.keywordAuthor Memory enhancement -
dc.subject.keywordPlus ANTERIOR CINGULATE CORTEX -
dc.subject.keywordPlus LONG-TERM-MEMORY -
dc.subject.keywordPlus SLEEP -
dc.subject.keywordPlus HIPPOCAMPUS -
dc.subject.keywordPlus FACILITATION -
dc.subject.keywordPlus INVOLVEMENT -
dc.subject.keywordPlus EXPRESSION -
dc.subject.keywordPlus RETRIEVAL -
dc.subject.keywordPlus REORGANIZATION -
dc.subject.keywordPlus ACTIVATION -


Items in Repository are protected by copyright, with all rights reserved, unless otherwise indicated.