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Myung, Kyungjae
Center for Genomic Integrity
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KARP-1 is induced by DNA damage in a p53- and ataxia telangiectasia mutated-dependent fashion

Author(s)
Myung, KBraastad, CHe, DMHendrickson, EA
Issued Date
1998-06
DOI
10.1073/pnas.95.13.7664
URI
https://scholarworks.unist.ac.kr/handle/201301/31100
Fulltext
https://www.pnas.org/content/95/13/7664
Citation
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, v.95, no.13, pp.7664 - 7669
Abstract
The KARP-1 (Ku86 Autoantigen Related Protein-1) gene, which is expressed from the human Ku86 autoantigen lotus, appears to play a role in mammalian DNA double-strand break repair as a regulator of the DNA-dependent protein kinase complex. Here, we demonstrate that KARP-1 gene expression is significantly up-regulated following exposure of cells to DNA damage. KARP-1 mRNA induction was completely dependent on the ataxia telangiectasia and p53 gene products, consistent with the presence of a p53 binding site within the second intron of the KARP-1 locus, These observations link ataxia telangiectasia, p53, and KARP-1 in a common pathway.
Publisher
NATL ACAD SCIENCES
ISSN
0027-8424
Keyword
DOUBLE-STRAND BREAKSV(D)J RECOMBINATIONIONIZING-RADIATIONCELLULAR-RESPONSEBINDING SITEINDUCTIONGENEGROWTHREPAIRMUTATIONS

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